Opelconazole, also known as PC-945, is an antifungal agent designed for inhalation therapy, targeting pulmonary fungal infections. Its mechanism of action involves the inhibition of lanosterol 14α-demethylase (CYP51A1), an enzyme crucial for ergosterol synthesis, thereby disrupting fungal cell membrane integrity and hindering growth. In vitro studies have demonstrated opelconazole's broad-spectrum antifungal activity against various pathogens, including Candida species (such as C. albicans, C. glabrata, C. krusei, and the multidrug-resistant C. auris), Cryptococcus neoformans, and Aspergillus species (notably A. fumigatus, A. carbonarius, and A. flavus).
MedKoo Cat#: 463873
Name: Opelconazole
CAS#: 1931946-73-4
Chemical Formula: C38H37F3N6O3
Exact Mass: 682.2879
Molecular Weight: 682.75
Elemental Analysis: C, 66.85; H, 5.46; F, 8.35; N, 12.31; O, 7.03
The following data is based on the product molecular weight 682.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
