Benzilonium bromide | CAS# 1050-48-2 | Anticholinergic

MedKoo Cat#: 413018 | Name: Benzilonium bromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Benzilonium bromide is an anticholinergic. Benzilonium bromide is a quarternary antimuscarinic agent with minimal passage of the blood-brain barrier.

Chemical Structure

Benzilonium bromide

CAS#1050-48-2

Theoretical Analysis

MedKoo Cat#: 413018

Name: Benzilonium bromide

CAS#: 1050-48-2

Chemical Formula: C22H28BrNO3

Exact Mass: 433.1253

Molecular Weight: 434.37

Elemental Analysis: C, 60.83; H, 6.50; Br, 18.40; N, 3.22; O, 11.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Benzilonium bromide; CI379; CI-379; CI 379

IUPAC/Chemical Name

1,1-Diethyl-3-hydroxypyrrolidinium bromide benzilate

InChi Key

GGMMWVHTLAENAS-UHFFFAOYSA-M

InChi Code

InChI=1S/C22H28NO3.BrH/c1-3-23(4-2)16-15-20(17-23)26-21(24)22(25,18-11-7-5-8-12-18)19-13-9-6-10-14-19;/h5-14,20,25H,3-4,15-17H2,1-2H3;1H/q+1;/p-1

SMILES Code

CC[N+]1(CC)CC(OC(C(C2=CC=CC=C2)(C3=CC=CC=C3)O)=O)CC1.[Br-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 434.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Stromme A. Benziloniumbromid ved hyperhidrose [Benzilonium bromide in hyperhydrosis]. Tidsskr Nor Laegeforen. 1969 Dec 15;89(24):1898-9. Norwegian. PMID: 5377175. 2: Jaup BH, Abrahamsson H, Stockbruegger RW, Rosengren K, Dotevall G. Effect of selective and non-selective antimuscarinics on rectosigmoid motility and gastrointestinal transit. Scand J Gastroenterol. 1985 Nov;20(9):1101-9. doi: 10.3109/00365528509088879. PMID: 3841410. 3: Stockbruegger RW, Seeberg S, Hellner L, Jaup BH, Dotevall G. Intragastric bacteria and nitrite after short-term treatment with different doses of antimuscarinic drugs. Scand J Gastroenterol. 1984 Jan;19(1):14-23. PMID: 6546806. 4: Kingsley PJ, Turner P. Class experiment in clinical pharmacology with benzilonium bromide, an anticholinergic drug. Eur J Clin Pharmacol. 1974;7(2):141-3. doi: 10.1007/BF00561329. PMID: 4851039. 5: Nyman CR. Urodynamic effects of intravenous benzilonium bromide in healthy subjects. Urol Int. 1980;35(5):363-8. doi: 10.1159/000280349. PMID: 7423681. 6: Nyman CR. Urodynamic effects of oral benzilonium bromide in healthy subjects. Urol Int. 1981;36(1):67-72. doi: 10.1159/000280395. PMID: 7257013. 7: BUCHEL L, LEVY J. PROPRI'ET'ES ANTICHOLINERGIQUES DE L'ESTER BENZYLIQUE DU BROMURE DE N-DI'ETHYL-1-1-HYDROXYPYRROLIDINIUM-3 (BROMURE DE BENZILONIUM) [ANTICHOLINERGIC PROPERTIES OF THE BENZYL ESTER OF N-DIETHYL-1,1-HYDROXYPYRROLIDIUM-3 BROMIDE (BENZILONIUM BROMIDE)]. Therapie. 1964 May-Jun;19:673-87. French. PMID: 14182951. 8: Jaska F. Inhibition of basal and pentagastrin-stimulated gastric acid secretion after treatment with benzilonium bromide and after selective proximal vagotomy. Scand J Gastroenterol. 1977;12(6):695-9. doi: 10.3109/00365527709181706. PMID: 929109. 9: Attwood D. Aggregation of antiacetylcholine drugs in aqueous solution: micellar properties of some diphenylmethane derivatives. J Pharm Pharmacol. 1976 May;28(5):407-9. doi: 10.1111/j.2042-7158.1976.tb04643.x. PMID: 6747. 10: Dahlström H, Leander K, Lindström B, Molander M. Quantitative determination of benzilonium bromide in plasma by gas chromatography-mass spectrometry after oxidation to benzophenone. J Chromatogr. 1980 Oct 10;183(4):511-3. doi: 10.1016/s0378-4347(00)81596-0. PMID: 7430303.