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MedKoo Cat#: 412013 | Name: CL-246738 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CL-246738 free base is a biochemical

Chemical Structure

CL-246738 free base
CL-246738 free base
CAS#81541-32-4

Theoretical Analysis

MedKoo Cat#: 412013

Name: CL-246738 free base

CAS#: 81541-32-4

Chemical Formula: C27H35N3O2

Exact Mass: 433.2729

Molecular Weight: 433.59

Elemental Analysis: C, 74.79; H, 8.14; N, 9.69; O, 7.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CL-246738 free base; CL246,738; CL 246,738
IUPAC/Chemical Name
Acridine, 3,6-bis(2-(1-piperidinyl)ethoxy)-
InChi Key
QKPASNYRBWHSBK-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H35N3O2/c1-3-11-29(12-4-1)15-17-31-24-9-7-22-19-23-8-10-25(21-27(23)28-26(22)20-24)32-18-16-30-13-5-2-6-14-30/h7-10,19-21H,1-6,11-18H2
SMILES Code
C1(OCCN2CCCCC2)=CC3=NC4=CC(OCCN5CCCCC5)=CC=C4C=C3C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 433.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lennard TW, Harris AL, Hales J, Dickinson A, Wolstencroft R, Halcrow P, Shenton BK, McDonald M, Lawrence GF, Taylor RM. A phase I study of immunostimulation and toxicity in patients with colorectal carcinoma using the immunomodulator 3,6-bis(2-piperidinoethoxy) acridine trihydrochloride (CL 246738). Eur J Cancer Clin Oncol. 1989 Nov;25(11):1571-6. doi: 10.1016/0277-5379(89)90299-x. PMID: 2591449. 2: Guimaraes L, Takehara HA, Alvarez JM. Protective effects of 3,6-bis-(2-piperidinoethoxyl) acridine trihydrochloride (CL-246738) in experimental acute Trypanosoma cruzi infection. Trans R Soc Trop Med Hyg. 1988;82(4):579-80. doi: 10.1016/0035-9203(88)90517-2. PMID: 3151414. 3: Ruszala-Mallon V, Silva J, Lumanglas AL, Durr FE, Wang BS. The mechanism of action of a synthetic immunomodulator, 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride (CL 246,738), in natural killer cell activation in animals. Int J Immunopharmacol. 1991;13(7):913-21. doi: 10.1016/0192-0561(91)90044-8. PMID: 1722194. 4: Wang BS, Lumanglas AL, Ruszala-Mallon VM, Durr FE. Induction of tumor- inhibitory macrophages with a novel synthetic immunomodulator, 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride (CL 246,738). J Immunol. 1985 Jul;135(1):679-83. PMID: 3839006. 5: Wang BS, Lumanglas AL, Silva J, Ruszala-Mallon VM, Durr FE. The mechanism of action of 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride (CL 246,738) in the potentiation of natural killer cells. J Immunol. 1986 Oct 15;137(8):2640-5. PMID: 3760570. 6: Lucas J, Raventos-Suarez C, Wang BS, Ruszala-Mallon VM, Gibbons JJ Jr. The effect of 3,6-bis(2-piperidinoethoxy) acridine trihydrochloride (CL 246, 738) on acute graft vs host reactions in mice. Int J Immunopharmacol. 1989;11(7):733-41. doi: 10.1016/0192-0561(89)90127-6. PMID: 2599713. 7: Morahan PS, Pinto A, Stewart D, Murasko DM, Brinton MA. Varying role of alpha/beta interferon in the antiviral efficacy of synthetic immunomodulators against Semliki Forest virus infection. Antiviral Res. 1991 Mar- Apr;15(3):241-54. doi: 10.1016/0166-3542(91)90070-8. PMID: 1653557. 8: Kunder SC, Kelly KM, Morahan PS. Biological response modifier-mediated resistance to herpesvirus infections requires induction of alpha/beta interferon. Antiviral Res. 1993 Jun;21(2):129-39. doi: 10.1016/0166-3542(93)90049-o. PMID: 7687839. 9: Lüllmann-Rauch R. Mucopolysaccharidosis (MPS) in ocular tissues as induced by amphiphilic di-cationic drugs. Lens Eye Toxic Res. 1990;7(3-4):263-79. PMID: 2129218. 10: Black PL, McKinnon KM, Wooden SL, Ussery MA. Antiviral activity of biological response modifiers in a murine model of AIDS. Requirement for augmentation of natural killer cell activity and synergy with oral AZT. Int J Immunopharmacol. 1996 Nov;18(11):633-50. doi: 10.1016/s0192-0561(96)00064-1. PMID: 9089007.

View History

CK-963

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