Synonym
CL 218872; CL218872; CL-218872; CL218,872; CL-218,872; CL 218,872
IUPAC/Chemical Name
1,2,4-Triazolo(4,3-b)pyridazine, 3-methyl-6-(3-(trifluoromethyl)phenyl)-
InChi Key
GUOQUXNJZHGPQF-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3
SMILES Code
FC(C1=CC(C2=NN3C(C=C2)=NN=C3C)=CC=C1)(F)F
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
278.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gee KW, Brinton RE, Yamamura HI. CL 218872 antagonism of diazepam induced loss of righting reflex: evidence for partial agonistic activity at the benzodiazepine receptor. Life Sci. 1983 Feb 28;32(9):1037-40. doi: 10.1016/0024-3205(83)90936-0. PMID: 6298552.
2: Skerritt JH, Macdonald RL. Benzodiazepine receptor ligand actions on GABA responses. Benzodiazepines, CL 218872, zopiclone. Eur J Pharmacol. 1984 May 18;101(1-2):127-34. doi: 10.1016/0014-2999(84)90038-4. PMID: 6086357.
3: Lista A, Arbilla S, Langer SZ. Modulation of the electrically evoked release of 5-[3H]hydroxytryptamine from rat cerebral cortex: effects of alpidem, CL 218872, and diazepam. J Neurochem. 1988 Nov;51(5):1414-21. doi: 10.1111/j.1471-4159.1988.tb01106.x. PMID: 2844992.
4: Gee KW, Yamamura HI. Selective anxiolytics: are the actions related to partial "agonist" activity or a preferential affinity for benzodiazepine receptor subtypes? Adv Biochem Psychopharmacol. 1983;38:1-9. PMID: 6142598.
5: Lecci A, Borsini F, Gragnani L, Volterra G, Meli A. Effect of psychotomimetics and some putative anxiolytics on stress-induced hyperthermia. J Neural Transm Gen Sect. 1991;83(1-2):67-76. doi: 10.1007/BF01244453. PMID: 1673345.
6: Goldberg ME, Salama AI, Patel JB, Malick JB. Novel non-benzodiazepine anxiolytics. Neuropharmacology. 1983 Dec;22(12B):1499-504. doi: 10.1016/0028-3908(83)90118-1. PMID: 6142427.
7: Im HK, Im WB, Hamilton BJ, Carter DB, Vonvoigtlander PF. Potentiation of gamma-aminobutyric acid-induced chloride currents by various benzodiazepine site agonists with the alpha 1 gamma 2, beta 2 gamma 2 and alpha 1 beta 2 gamma 2 subtypes of cloned gamma-aminobutyric acid type A receptors. Mol Pharmacol. 1993 Oct;44(4):866-70. PMID: 7901754.
8: Gee KW, Morelli M, Yamamura HI. The effect of temperature on CL 218872 and propyl beta-carboline-3-carboxylate inhibition of [3H]-flunitrazepam binding in rat brain. Biochem Biophys Res Commun. 1982 Apr 29;105(4):1532-7. doi: 10.1016/0006-291x(82)90962-7. PMID: 6125147.
9: Gardner CR. Agonist and inverse agonist effects of CL 218872 on benzodiazepine receptors. Neurosci Lett. 1984 Sep 28;51(1):1-6. doi: 10.1016/0304-3940(84)90253-2. PMID: 6096768.
10: Zezula J, Cortés R, Probst A, Palacios JM. Benzodiazepine receptor sites in the human brain: autoradiographic mapping. Neuroscience. 1988 Jun;25(3):771-95. doi: 10.1016/0306-4522(88)90036-x. PMID: 2841624.
