Cholesteryl Hemisuccinate was reported to have anticancer activity. Cholesteryl Hemisuccinate is a weakly acidic cholesterol derivative. It inhibits the growth of murine C1498 myeloid and L1210 lymphocytic leukemia cells when used at concentrations of 50 and 150 μM, respectively. Cholesteryl hemisuccinate acts as an ionizable anionic surfactant and is commonly used to stabilize DOPE-rich pH-sensitive liposomes. It has also been used as an emulsifying agent in various vesicular drug delivery systems for anticancer drugs, antibiotics, and oligonucleotides and to solubilize various proteins including chemokine receptor 1 as well as erythrocyte ghosts.
MedKoo Cat#: 414882
Name: Cholesteryl Hemisuccinate
CAS#: 1510-21-0
Chemical Formula: C31H50O4
Exact Mass: 486.3709
Molecular Weight: 486.74
Elemental Analysis: C, 76.50; H, 10.35; O, 13.15
The following data is based on the product molecular weight 486.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
