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MedKoo Cat#: 414879 | Name: HSPC

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HSPC used in many FDA approved liposomal drug formulations, It is hydrogenated soybean phosphatidylcholine to improve the chemical and physical stability of the lipososmes prepared. It has been used in two important FDA approved liposomal drugs Doxil® and AmBisome®.

Chemical Structure

HSPC
HSPC
CAS# 97281-48-6

Theoretical Analysis

MedKoo Cat#: 414879

Name: HSPC

CAS#:  97281-48-6

Chemical Formula:

Exact Mass:

Molecular Weight:

Elemental Analysis:

Price and Availability

Size Price Availability Quantity
200mg USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
HSPC; L-α-phosphatidylcholine, hydrogenated (Soy); Hydro Soy PC;
IUPAC/Chemical Name
hydrogenated ≥99%L-α-Phosphatidylcholinefrom soybean (TLC) (HSPC)
InChi Key
InChi Code
SMILES Code
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
[Sara Gaspani, Barbara Milani, Access to liposomal generic formulations: beyond AmBisome and Doxil/Caelyx. Generics and Biosimilars Initiative Journal (GaBI Journal). 2013;2(2):60-2. DOI: 10.5639/gabij.2013.0202.022]

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ding Y, Wang W, Ma D, Liang G, Kang Z, Xue Y, Zhang Y, Wang L, Heng J, Zhang Y, Liu F. Smarca5 mediated epigenetic programming facilitates fetal HSPC development in vertebrates. Blood. 2020 Aug 5:blood.2020005219. doi: 10.1182/blood.2020005219. Epub ahead of print. PMID: 32756943. 2: Carroll D, St Clair DK. Hematopoietic Stem Cells: Normal Versus Malignant. Antioxid Redox Signal. 2018 Dec 1;29(16):1612-1632. doi: 10.1089/ars.2017.7326. Epub 2017 Dec 20. PMID: 29084438; PMCID: PMC6207150. 3: Hess NJ, Lindner PN, Vazquez J, Grindel S, Hudson AW, Stanic AK, Ikeda A, Hematti P, Gumperz JE. Different Human Immune Lineage Compositions Are Generated in Non-Conditioned NBSGW Mice Depending on HSPC Source. Front Immunol. 2020 Oct 19;11:573406. doi: 10.3389/fimmu.2020.573406. PMID: 33193358; PMCID: PMC7604455. 4: Stewen J, Bixel MG. Intravital Imaging of Blood Flow and HSPC Homing in Bone Marrow Microvessels. Methods Mol Biol. 2019;2017:109-121. doi: 10.1007/978-1-4939-9574-5_9. PMID: 31197772. 5: Tedesco S, Ciciliot S, Menegazzo L, D'Anna M, Scattolini V, Cappellari R, Cignarella A, Avogaro A, Albiero M, Fadini GP. Pharmacologic PPAR-γ Activation Reprograms Bone Marrow Macrophages and Partially Rescues HSPC Mobilization in Human and Murine Diabetes. Diabetes. 2020 Jul;69(7):1562-1572. doi: 10.2337/db19-0640. Epub 2020 Apr 28. PMID: 32345753. 6: Liu M, Jin S, Yan H, Du S. Effect of oxymatrine HSPC liposomes on improving bioavailability, liver target distribution and hepatoprotective activity of oxymatrine. Eur J Pharm Sci. 2017 Jun 15;104:212-220. doi: 10.1016/j.ejps.2017.03.048. Epub 2017 Apr 5. PMID: 28389275. 7: Li D, Xue W, Li M, Dong M, Wang J, Wang X, Li X, Chen K, Zhang W, Wu S, Zhang Y, Gao L, Chen Y, Chen J, Zhou BO, Zhou Y, Yao X, Li L, Wu D, Pan W. VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche. Nature. 2018 Dec;564(7734):119-124. doi: 10.1038/s41586-018-0709-7. Epub 2018 Nov 19. PMID: 30455424; PMCID: PMC6492262. 8: Shore ND. Darolutamide (ODM-201) for the treatment of prostate cancer. Expert Opin Pharmacother. 2017 Jun;18(9):945-952. doi: 10.1080/14656566.2017.1329820. Epub 2017 May 24. PMID: 28490267. 9: Hoyer FF, Zhang X, Coppin E, Vasamsetti SB, Modugu G, Schloss MJ, Rohde D, McAlpine CS, Iwamoto Y, Libby P, Naxerova K, Swirski FK, Dutta P, Nahrendorf M. Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes Mellitus. Circulation. 2020 Jul 21;142(3):244-258. doi: 10.1161/CIRCULATIONAHA.120.046038. Epub 2020 Apr 22. PMID: 32316750; PMCID: PMC7375017. 10: Dolstra H, Roeven MWH, Spanholtz J, Hangalapura BN, Tordoir M, Maas F, Leenders M, Bohme F, Kok N, Trilsbeek C, Paardekooper J, van der Waart AB, Westerweel PE, Snijders TJF, Cornelissen J, Bos G, Pruijt HFM, de Graaf AO, van der Reijden BA, Jansen JH, van der Meer A, Huls G, Cany J, Preijers F, Blijlevens NMA, Schaap NM. Successful Transfer of Umbilical Cord Blood CD34+ Hematopoietic Stem and Progenitor-derived NK Cells in Older Acute Myeloid Leukemia Patients. Clin Cancer Res. 2017 Aug 1;23(15):4107-4118. doi: 10.1158/1078-0432.CCR-16-2981. Epub 2017 Mar 9. PMID: 28280089.