Synonym
DSPC; 1,2-Distearoyl-sn-glycero-3-PC; Coatsome MC 8080;
IUPAC/Chemical Name
1,2-Distearoyl-sn-glycero-3-phosphocholine
InChi Key
NRJAVPSFFCBXDT-HUESYALOSA-N
InChi Code
InChI=1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1
SMILES Code
CCCCCCCCCCCCCCCCCC(O[C@@H](COP([O-])(OCC[N+](C)(C)C)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Ethanol |
25.0 |
31.64 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
790.16
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kilic S, Bolukcu ES. Phase behavior of DSPC/PEG40St mixtures at higher emulsifier contents. Colloids Surf B Biointerfaces. 2018 Nov 1;171:368-376. doi: 10.1016/j.colsurfb.2018.07.046. Epub 2018 Jul 24. PMID: 30059852.
2: Unga J, Omata D, Kudo N, Ueno S, Munakata L, Shima T, Suzuki R, Maruyama K. Development and evaluation of stability and ultrasound response of DSPC-DPSG- based freeze-dried microbubbles. J Liposome Res. 2019 Dec;29(4):368-374. doi: 10.1080/08982104.2018.1556294. Epub 2019 Jan 28. PMID: 30526185.
3: Kamble S, Patil S, Appala VRM. Nano-mechanical characterization of asymmetric DLPC/DSPC supported lipid bilayers. Chem Phys Lipids. 2021 Jan;234:105007. doi: 10.1016/j.chemphyslip.2020.105007. Epub 2020 Nov 5. PMID: 33160952.
4: Kulkarni JA , Witzigmann D , Leung J , Tam YYC , Cullis PR . On the role of helper lipids in lipid nanoparticle formulations of siRNA. Nanoscale. 2019 Nov 21;11(45):21733-21739. doi: 10.1039/c9nr09347h. PMID: 31713568.
5: Hashemzadeh H, Javadi H, Darvishi MH. Study of Structural stability and formation mechanisms in DSPC and DPSM liposomes: A coarse-grained molecular dynamics simulation. Sci Rep. 2020 Feb 4;10(1):1837. doi: 10.1038/s41598-020-58730-z. PMID: 32020000; PMCID: PMC7000798.
6: Oguchi T, Sakai K, Sakai H, Abe M. DSPC/DLPC mixed films supported on silica: a QCM-D and friction force study. J Oleo Sci. 2011;60(4):177-83. doi: 10.5650/jos.60.177. PMID: 21427514.
7: Kulkarni JA, Myhre JL, Chen S, Tam YYC, Danescu A, Richman JM, Cullis PR. Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA. Nanomedicine. 2017 May;13(4):1377-1387. doi: 10.1016/j.nano.2016.12.014. Epub 2016 Dec 28. PMID: 28038954.
8: Panda D, Manickam S. Recent advancements in the sonophotocatalysis (SPC) and doped-sonophotocatalysis (DSPC) for the treatment of recalcitrant hazardous organic water pollutants. Ultrason Sonochem. 2017 May;36:481-496. doi: 10.1016/j.ultsonch.2016.12.022. Epub 2016 Dec 23. PMID: 28069236.
9: Reji RM, Siddikuzzaman, V M BG. ATRA Entrapped in DSPC Liposome Enhances Anti-metastasis Effect on Lung and Liver During B16F10 Cell Line Metastasis in C57BL6 Mice. Anticancer Agents Med Chem. 2017;17(6):875-884. doi: 10.2174/1871520616666160927103458. PMID: 27677688.
10: Yin T, Cao X, Liu X, Wang J, Shi C, Su J, Zhang Y, Gou J, He H, Guo H, Tang X, Zhao Y. Interfacial molecular interactions based on the conformation recognition between the insoluble antitumor drug AD-1 and DSPC. Colloids Surf B Biointerfaces. 2016 Oct 1;146:902-9. doi: 10.1016/j.colsurfb.2016.07.040. Epub 2016 Jul 20. PMID: 27469574.
