Synonym
CJ-033466; CJ033466; CJ 033466
IUPAC/Chemical Name
Imidazo(1,2-a)pyridine-8-carboxamide, 5-amino-6-chloro-2-methyl-N-((1-(2-methylpropyl)-4-piperidinyl)methyl)-
InChi Key
ISKHMDNIWXPUGR-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H28ClN5O/c1-12(2)10-24-6-4-14(5-7-24)9-22-19(26)15-8-16(20)17(21)25-11-13(3)23-18(15)25/h8,11-12,14H,4-7,9-10,21H2,1-3H3,(H,22,26)
SMILES Code
O=C(C1=CC(Cl)=C(N)N2C1=NC(C)=C2)NCC3CCN(CC(C)C)CC3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
377.92
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Toga T, Kohmura Y, Kawatsu R. The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go- related gene (hERG)-blocking activities. J Pharmacol Sci. 2007 Oct;105(2):207-10. doi: 10.1254/jphs.sc0070243. Epub 2007 Oct 6. PMID: 17928736.
2: Tsuchida Y, Hatao F, Fujisawa M, Murata T, Kaminishi M, Seto Y, Hori M, Ozaki H. Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti- inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus. Gut. 2011 May;60(5):638-47. doi: 10.1136/gut.2010.227546. Epub 2010 Nov 29. PMID: 21115544; PMCID: PMC3071096.
3: Boakye PA, Stenkamp-Strahm C, Bhattarai Y, Heckman MD, Brierley SM, Pasilis SP, Balemba OB. 5-HT(3) and 5-HT(4) receptors contribute to the anti-motility effects of Garcinia buchananii bark extract in the guinea-pig distal colon. Neurogastroenterol Motil. 2012 Jan;24(1):e27-40. doi: 10.1111/j.1365-2982.2011.01807.x. Epub 2011 Nov 10. PMID: 22074563.
4: Mikami T, Ochi Y, Suzuki K, Saito T, Sugie Y, Sakakibara M. 5-Amino-6-chloro- N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-alpha]pyridine-8-carbox amide (CJ-033,466), a novel and selective 5-hydroxytryptamine4 receptor partial agonist: pharmacological profile in vitro and gastroprokinetic effect in conscious dogs. J Pharmacol Exp Ther. 2008 Apr;325(1):190-9. doi: 10.1124/jpet.107.133850. Epub 2008 Jan 15. PMID: 18198343.
