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MedKoo Cat#: 463824 | Name: AK-42

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AK-42 is a novel potent and specific inhibitor of CLC-2, displaying unprecedented selectivity over CLC-1, the closest CLC-2 homolog, and exhibiting no off-target engagement against a panel of 61 common channels, receptors, and transporters expressed in brain tissue.

Chemical Structure

AK-42
AK-42
CAS#15437-29-3

Theoretical Analysis

MedKoo Cat#: 463824

Name: AK-42

CAS#: 15437-29-3

Chemical Formula: C20H15Cl2NO3

Exact Mass: 387.0429

Molecular Weight: 388.24

Elemental Analysis: C, 61.87; H, 3.89; Cl, 18.26; N, 3.61; O, 12.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AK-42; AK42; AK 42;
IUPAC/Chemical Name
2-((3-(benzyloxy)-2,6-dichlorophenyl)amino)benzoic acid
InChi Key
OZERPKICLJNSGP-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H15Cl2NO3/c21-15-10-11-17(26-12-13-6-2-1-3-7-13)18(22)19(15)23-16-9-5-4-8-14(16)20(24)25/h1-11,23H,12H2,(H,24,25)
SMILES Code
O=C(O)C1=CC=CC=C1NC2=C(Cl)C=CC(OCC3=CC=CC=C3)=C2Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 388.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Koster AK, Reese AL, Kuryshev Y, Wen X, McKiernan KA, Gray EE, Wu C, Huguenard JR, Maduke M, Du Bois J. Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32711-32721. doi: 10.1073/pnas.2009977117. Epub 2020 Dec 4. PMID: 33277431; PMCID: PMC7768775.