FR-168888 free base | CAS# 168620-45-9 | Biochemical

MedKoo Cat#: 575675 | Name: FR-168888 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FR-168888 free base is a new Na+/H+ exchange inhibitor. FR-168888 has a strong inhibitory effect on Na+/H+ exchange and has been shown to protect the heart from arrhythmia and myocardial cell death in ischemic and reperfused situations.

Chemical Structure

FR-168888 free base

CAS#168620-45-9

Theoretical Analysis

MedKoo Cat#: 575675

Name: FR-168888 free base

CAS#: 168620-45-9

Chemical Formula: C13H14N4O2

Exact Mass: 258.1117

Molecular Weight: 258.28

Elemental Analysis: C, 60.45; H, 5.46; N, 21.69; O, 12.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

FR-168888 free base; FR168888 free base; FR 168888 free base

IUPAC/Chemical Name

Benzamide, N-(aminoiminomethyl)-3-(hydroxymethyl)-5-(1H-pyrrol-1-yl)-

InChi Key

GGGBRMYYNXZUDS-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H14N4O2/c14-13(15)16-12(19)10-5-9(8-18)6-11(7-10)17-3-1-2-4-17/h1-7,18H,8H2,(H4,14,15,16,19)

SMILES Code

NC(=N)NC(=O)c1cc(CO)cc(c1)n2cccc2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 258.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhu BM, Miyamoto S, Kamiya K, Komori S, Hashimoto K. Inhibitory effects of pre-ischemic and post-ischemic treatment with FR 168888, a Na+/H+ exchange inhibitor, on reperfusion-induced ventricular arrhythmias in anesthetized rat. Jpn J Pharmacol. 2002 Jan;88(1):93-9. PubMed PMID: 11855683. 2: Suzuki T, Yamaya M, Sekizawa K, Hosoda M, Yamada N, Ishizuka S, Nakayama K, Yanai M, Numazaki Y, Sasaki H. Bafilomycin A(1) inhibits rhinovirus infection in human airway epithelium: effects on endosome and ICAM-1. Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1115-27. PubMed PMID: 11350790. 3: Ohara F, Sugimoto T, Yamamoto N, Ohkubo K, Ozaki T, Maeda K, Seki J, Goto T. Protective effect of FR168888, a new Na+/H+ exchange inhibitor, on ischemia and reperfusion-induced arrhythmia and myocardial infarction in rats: in comparison with other cardioprotective compounds. Jpn J Pharmacol. 1999 Aug;80(4):295-302. PubMed PMID: 10496329.