BIIB091 is a novel potent, highly selective BTK inhibitor for the treatment of multiple sclerosis. BIIB091 binds the BTK protein in a DFG-in confirmation designed to sequester Tyr-551, an important phosphorylation site on BTK, into an inactive conformation with excellent affinity. Preclinical studies demonstrated BIB091 to be a high potency molecule with good drug-like properties and a safety/tolerability profile suitable for clinical development as a highly selective, reversible BTKi for treating autoimmune diseases such as MS.
MedKoo Cat#: 463805
Name: BIIB091
CAS#: 2247614-80-6
Chemical Formula: C28H34N10O2
Exact Mass: 542.2866
Molecular Weight: 542.65
Elemental Analysis: C, 61.98; H, 6.32; N, 25.81; O, 5.90
The following data is based on the product molecular weight 542.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
