Synonym
FPL 12924; FPL-12944AA; PR 934-423; PR-934-423; Remacemide
IUPAC/Chemical Name
Acetamide, 2-amino-N-(1-methyl-1,2-diphenylethyl)-, (+-)-
InChi Key
YSGASDXSLKIKOD-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H20N2O/c1-17(19-16(20)13-18,15-10-6-3-7-11-15)12-14-8-4-2-5-9-14/h2-11H,12-13,18H2,1H3,(H,19,20)
SMILES Code
CC(Cc1ccccc1)(NC(=O)CN)c2ccccc2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
268.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wesnes KA, Edgar C, Dean AD, Wroe SJ. The cognitive and psychomotor effects of remacemide and carbamazepine in newly diagnosed epilepsy. Epilepsy Behav. 2009 Mar;14(3):522-8. doi: 10.1016/j.yebeh.2008.11.012. Epub 2008 Dec 25. PubMed PMID: 19111629.
2: Borowicz KK, Malek R, Luszczki JJ, Ratnaraj N, Patsalos PN, Czuczwar SJ. Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock. Epilepsy Behav. 2007 Aug;11(1):6-12. Epub 2007 Jun 29. PubMed PMID: 17602881.
3: Wright LK, Pearson EC, Hammond TG, Paule MG. Behavioral effects associated with chronic ketamine or remacemide exposure in rats. Neurotoxicol Teratol. 2007 May-Jun;29(3):348-59. Epub 2007 Jan 16. PubMed PMID: 17291718.
4: Małek R, Borowicz KK, Kimber-Trojnar Z, Sobieszek G, Piskorska B, Czuczwar SJ. Remacemide--a novel potential antiepileptic drug. Pol J Pharmacol. 2003 Sep-Oct;55(5):691-8. Review. PubMed PMID: 14704464.
5: Calabresi P, Marti M, Picconi B, Saulle E, Costa C, Centonze D, Pisani F, Bernardi G. Lamotrigine and remacemide protect striatal neurons against in vitro ischemia: an electrophysiological study. Exp Neurol. 2003 Aug;182(2):461-9. PubMed PMID: 12895457.
6: Brodie MJ, Wroe SJ, Dean AD, Holdich TA, Whitehead J, Stevens JW. Efficacy and Safety of Remacemide versus Carbamazepine in Newly Diagnosed Epilepsy: Comparison by Sequential Analysis. Epilepsy Behav. 2002 Apr;3(2):140-146. PubMed PMID: 12609415.
