Ciproxifan | CAS# 184025-18-1 (free base) | histamine H(3) receptor antagonist

MedKoo Cat#: 412941 | Name: Ciproxifan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ciproxifan is a potent histamine H(3) receptor antagonist.

Chemical Structure

Ciproxifan

CAS#184025-18-1 (free base)

Theoretical Analysis

MedKoo Cat#: 412941

Name: Ciproxifan

CAS#: 184025-18-1 (free base)

Chemical Formula: C16H18N2O2

Exact Mass: 270.1368

Molecular Weight: 270.33

Elemental Analysis: C, 71.09; H, 6.71; N, 10.36; O, 11.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

184025-18-1 (free base);

Synonym

Ciproxifan; FUB359; FUB-359; FUB 359

IUPAC/Chemical Name

(4-(3-(1H-imidazol-5-yl)propoxy)phenyl)(cyclopropyl)methanone

InChi Key

ACQBHJXEAYTHCY-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H18N2O2/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14/h5-8,10-12H,1-4,9H2,(H,17,18)

SMILES Code

O=C(c1ccc(OCCCc2[nH]cnc2)cc1)C3CC3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 270.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nair AS. Ciproxifan in preventing inhalational anesthetic-induced neurotoxicity! Saudi J Anaesth. 2018 Jan-Mar;12(1):162-163. doi: 10.4103/sja.SJA_394_17. PMID: 29416490; PMCID: PMC5789493. 2: Hagenow S, Stasiak A, Ramsay RR, Stark H. Ciproxifan, a histamine H3 receptor antagonist, reversibly inhibits monoamine oxidase A and B. Sci Rep. 2017 Jan 13;7:40541. doi: 10.1038/srep40541. PMID: 28084411; PMCID: PMC5233962. 3: Chauveau F, De Job E, Poly-Thomasson B, Cavroy R, Thomasson J, Fromage D, Beracochea D. Procognitive impact of ciproxifan (a histaminergic H3 receptor antagonist) on contextual memory retrieval after acute stress. CNS Neurosci Ther. 2019 Aug;25(8):832-841. doi: 10.1111/cns.13113. Epub 2019 May 15. PMID: 31094061; PMCID: PMC6630007. 4: Mani V, Jaafar SM, Azahan NSM, Ramasamy K, Lim SM, Ming LC, Majeed ABA. Ciproxifan improves cholinergic transmission, attenuates neuroinflammation and oxidative stress but does not reduce amyloid level in transgenic mice. Life Sci. 2017 Jul 1;180:23-35. doi: 10.1016/j.lfs.2017.05.013. Epub 2017 May 10. PMID: 28501482. 5: Lu CW, Lin TY, Chang CY, Huang SK, Wang SJ. Ciproxifan, a histamine H3 receptor antagonist and inverse agonist, presynaptically inhibits glutamate release in rat hippocampus. Toxicol Appl Pharmacol. 2017 Mar 15;319:12-21. doi: 10.1016/j.taap.2017.01.017. Epub 2017 Jan 27. PMID: 28132918. 6: Pillot C, Héron A, Schwartz JC, Arrang JM. Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum. Eur J Neurosci. 2003 Jan;17(2):307-14. doi: 10.1046/j.1460-9568.2003.02422.x. PMID: 12542667. 7: Chauveau F, Laudereau K, Libourel PA, Gervasoni D, Thomasson J, Poly B, Pierard C, Beracochea D. Ciproxifan improves working memory through increased prefrontal cortex neural activity in sleep-restricted mice. Neuropharmacology. 2014 Oct;85:349-56. doi: 10.1016/j.neuropharm.2014.04.017. Epub 2014 May 4. PMID: 24796256. 8: Bardgett ME, Davis NN, Schultheis PJ, Griffith MS. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem. 2011 Jan;95(1):64-72. doi: 10.1016/j.nlm.2010.10.008. Epub 2010 Nov 10. PMID: 21073971; PMCID: PMC3034295. 9: Ding F, Zheng L, Liu M, Chen R, Leung LS, Luo T. Ciproxifan, an H3 receptor antagonist, improves short-term recognition memory impaired by isoflurane anesthesia. J Anesth. 2016 Aug;30(4):684-90. doi: 10.1007/s00540-016-2189-y. Epub 2016 May 19. PMID: 27193325. 10: Bardgett ME, Points M, Kleier J, Blankenship M, Griffith MS. The H3 antagonist, ciproxifan, alleviates the memory impairment but enhances the motor effects of MK-801 (dizocilpine) in rats. Neuropharmacology. 2010 Nov;59(6):492-502. doi: 10.1016/j.neuropharm.2010.07.004. Epub 2010 Jul 16. PMID: 20621107; PMCID: PMC2946466.