Gap19 is a nonapeptide derivative of connexin43 (Cx43) and an inhibitor of Cx43 hemichannels. It suppresses the membrane charge transfer (Qm) in HeLa cells expressing Cx43, as well as Cx43 hemichannel currents in isolated guinea pig cardiomyocytes when used at a concentration of 100 µM. Gap19 inhibits glutamate-induced ATP release, a marker of Cx43 hemichannel activity, in primary mouse astrocytes. In vivo, Gap19 decreases cortical neuronal loss, infarct volume, and the number of errors in a foot fault test in a mouse model of cerebral ischemia and reperfusion injury induced by middle cerebral artery occlusion. It also reduces infarct size in a mouse model of myocardial ischemia and reperfusion injury induced by ligation of the left anterior descending (LAD) artery when administered at a dose of 25 mg/kg.
MedKoo Cat#: 463786
Name: Gap19 trifluoroacetate salt
CAS#: unknown
Chemical Formula: C57H97F3N14O15
Exact Mass: 0.0000
Molecular Weight: 1275.48
Elemental Analysis: C, 53.68; H, 7.67; F, 4.47; N, 15.37; O, 18.82
The following data is based on the product molecular weight 1,275.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
