PPEF | CAS#unknown | Escherichia coli Topoisomerase IA Inhibitor

MedKoo Cat#: 463765 | Name: PPEF

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PPEF is a novel Escherichia coli Topoisomerase IA Inhibitor and Potential Antibacterial Agent.

Chemical Structure

PPEF

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463765

Name: PPEF

CAS#: unknown

Chemical Formula: C29H32N6O

Exact Mass: 480.2638

Molecular Weight: 480.62

Elemental Analysis: C, 72.47; H, 6.71; N, 17.49; O, 3.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PPEF;

IUPAC/Chemical Name

2'-(4-ethoxyphenyl)-5-(4-propylpiperazin-1-yl)-1H,1'H-2,5'-bibenzo[d]imidazole

InChi Key

MPFLRCXYUNXTMX-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H32N6O/c1-3-13-34-14-16-35(17-15-34)22-8-12-25-27(19-22)33-29(31-25)21-7-11-24-26(18-21)32-28(30-24)20-5-9-23(10-6-20)36-4-2/h5-12,18-19H,3-4,13-17H2,1-2H3,(H,30,32)(H,31,33)

SMILES Code

CCOC1=CC=C(C2=NC3=CC(C4=NC5=CC(N6CCN(CCC)CC6)=CC=C5N4)=CC=C3N2)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 480.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Singh R, Pandey S, Sur S, Tandon V. PPEF: A bisbenzimdazole potent antimicrobial agent interacts at acidic triad of catalytic domain of E. coli topoisomerase IA. Biochim Biophys Acta Gen Subj. 2019 Oct;1863(10):1524-1535. doi: 10.1016/j.bbagen.2019.05.015. Epub 2019 May 27. PMID: 31145964. 2: Sinha D, Pandey S, Singh R, Tiwari V, Sad K, Tandon V. Synergistic efficacy of Bisbenzimidazole and Carbonyl Cyanide 3-Chlorophenylhydrazone combination against MDR bacterial strains. Sci Rep. 2017 Mar 17;7:44419. doi: 10.1038/srep44419. PMID: 28303897; PMCID: PMC5355889.