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MedKoo Cat#: 412878 | Name: Ciclotizolam

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ciclotizolam is a drug which is a thienotriazolodiazepine derivative. It is a partial agonist for the benzodiazepine site of the GABAA receptor, with similar binding affinity to related compounds like brotizolam, but a low efficacy.

Chemical Structure

Ciclotizolam
Ciclotizolam
CAS#58765-21-2

Theoretical Analysis

MedKoo Cat#: 412878

Name: Ciclotizolam

CAS#: 58765-21-2

Chemical Formula: C20H18BrClN4S

Exact Mass: 460.0124

Molecular Weight: 461.81

Elemental Analysis: C, 52.02; H, 3.93; Br, 17.30; Cl, 7.68; N, 12.13; S, 6.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ciclotizolam; We973; We-973; We 973
IUPAC/Chemical Name
2-Bromo-4-(o-chlorophenyl)-9-cyclohexyl-6H-thieno(3,2-f)-s-triazolo(4,3-a)(1,4)diazepine
InChi Key
ZOSHXIXUCKESEG-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H18BrClN4S/c21-16-10-14-18(13-8-4-5-9-15(13)22)23-11-17-24-25-19(26(17)20(14)27-16)12-6-2-1-3-7-12/h4-5,8-10,12H,1-3,6-7,11H2
SMILES Code
ClC1=CC=CC=C1C2=NCC3=NN=C(C4CCCCC4)N3C5=C2C=C(Br)S5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 461.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ikeda M, Weber KH, Bechtel WD, Malatynska E, Yamamura HI. Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles. Life Sci. 1989;45(4):349-58. doi: 10.1016/0024-3205(89)90145-8. PMID: 2569655. 2: Weber KH, Kuhn FJ, Böke-Kuhn K, Lehr E, Danneberg PB, Hommer D, Paul SM, Skolnick P. Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines'). Eur J Pharmacol. 1985 Feb 12;109(1):19-31. doi: 10.1016/0014-2999(85)90535-7. PMID: 2986988.