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MedKoo Cat#: 412855 | Name: Chrysosplenol C

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chrysosplenol C is a trimethoxyflavone that is the 3,7,3'-trimethyl ether derivative of quercetagetin. It has a role as a plant metabolite, an antineoplastic agent and an antiviral agent. It is a trihydroxyflavone and a trimethoxyflavone. It derives from a quercetagetin.

Chemical Structure

Chrysosplenol C
Chrysosplenol C
CAS#23370-16-3

Theoretical Analysis

MedKoo Cat#: 412855

Name: Chrysosplenol C

CAS#: 23370-16-3

Chemical Formula: C18H16O8

Exact Mass: 360.0845

Molecular Weight: 360.32

Elemental Analysis: C, 60.00; H, 4.48; O, 35.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Chrysosplenol C
IUPAC/Chemical Name
5,6-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one
InChi Key
QQBSPLCHDUCBNM-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H16O8/c1-23-10-6-8(4-5-9(10)19)17-18(25-3)16(22)13-11(26-17)7-12(24-2)14(20)15(13)21/h4-7,19-21H,1-3H3
SMILES Code
COC1=C(c2cc(OC)c(O)cc2)Oc3c(C1=O)c(O)c(O)c(OC)c3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 360.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Venkateswararao E, Son MJ, Sharma N, Manickam M, Boggu P, Kim YH, Woo SH, Jung SH. Exploration of Pharmacophore in Chrysosplenol C as Activator in Ventricular Myocyte Contraction. ACS Med Chem Lett. 2015 May 20;6(7):758-63. doi: 10.1021/acsmedchemlett.5b00043. PMID: 26191362; PMCID: PMC4499824. 2: Ng CL, Lee SE, Lee JK, Kim TH, Jang WS, Choi JS, Kim YH, Kim JK, Park JS. Solubilization and formulation of chrysosplenol C in solid dispersion with hydrophilic carriers. Int J Pharm. 2016 Oct 15;512(1):314-321. doi: 10.1016/j.ijpharm.2016.08.062. Epub 2016 Sep 1. PMID: 27593897. 3: Son MJ, Kim HK, Huong do TT, Kim YH, Van Sung T, Cuong NM, Woo SH. Chrysosplenol C increases contraction in rat ventricular myocytes. J Cardiovasc Pharmacol. 2011 Feb;57(2):259-62. doi: 10.1097/FJC.0b013e318201f119. PMID: 21052017. 4: Garayev E, Herbette G, Di Giorgio C, Chiffolleau P, Roux D, Sallanon H, Ollivier E, Elias R, Baghdikian B. New sesquiterpene acid and inositol derivatives from Inula montana L. Fitoterapia. 2017 Jul;120:79-84. doi: 10.1016/j.fitote.2017.05.011. Epub 2017 Jun 1. PMID: 28579553. 5: Garayev E, Di Giorgio C, Herbette G, Mabrouki F, Chiffolleau P, Roux D, Sallanon H, Ollivier E, Elias R, Baghdikian B. Bioassay-guided isolation and UHPLC-DAD-ESI-MS/MS quantification of potential anti-inflammatory phenolic compounds from flowers of Inula montana L. J Ethnopharmacol. 2018 Nov 15;226:176-184. doi: 10.1016/j.jep.2018.08.005. Epub 2018 Aug 10. PMID: 30102993. 6: Semple SJ, Nobbs SF, Pyke SM, Reynolds GD, Flower RL. Antiviral flavonoid from Pterocaulon sphacelatum, an Australian Aboriginal medicine. J Ethnopharmacol. 1999 Dec 15;68(1-3):283-8. doi: 10.1016/s0378-8741(99)00050-1. PMID: 10624889. 7: Trendafilova A, Todorova M, Genova V, Shestakova P, Dimitrov D, Jadranine M, Milosavljevic S. New pseudoguaiane derivatives from Inula aschersoniana Janka var. aschersoniana. Nat Prod Commun. 2014 Aug;9(8):1123-4. PMID: 25233586. 8: Zheng LH, Hao XJ, Yuan CM, Huang LJ, Zhang JX, Dong F, Fan TY, Wu GH, Chen Y, Ma Y, Fan YM, Gu W. [Study on chemical constituents of Inula cappa]. Zhongguo Zhong Yao Za Zhi. 2015 Feb;40(4):672-8. Chinese. PMID: 26137689. 9: Huong DT, Luong DV, Thao TT, Sung TV. A new flavone and cytotoxic activity of flavonoid constituents isolated from Miliusa balansae (Annonaceae). Pharmazie. 2005 Aug;60(8):627-9. PMID: 16124409. 10: Huong DT, Kamperdick C, Sung TV. Homogentisic acid derivatives from Miliusa balansae. J Nat Prod. 2004 Mar;67(3):445-7. doi: 10.1021/np030195z. PMID: 15043427.