IUPAC/Chemical Name
beta-D-Ribofuranuronic acid, 3-((2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-1-(6-amino-9H-purin-9-yl)-1,3-dideoxy-, (S)-
InChi Key
TXYMIIPGRTXESZ-JDZCFQESSA-N
InChi Code
InChI=1S/C20H23N7O6/c1-32-10-4-2-9(3-5-10)6-11(21)18(29)26-12-14(28)19(33-15(12)20(30)31)27-8-25-13-16(22)23-7-24-17(13)27/h2-5,7-8,11-12,14-15,19,28H,6,21H2,1H3,(H,26,29)(H,30,31)(H2,22,23,24)/t11-,12-,14+,15-,19+/m0/s1
SMILES Code
O[C@H]1[C@H](N2C=NC3=C(N)N=CN=C23)O[C@H](C(O)=O)[C@H]1NC([C@@H](N)CC4=CC=C(OC)C=C4)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
457.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yamashita M, Kawai Y, Uchida I, Komori T, Kohsaka M, Imanaka H, Sakane K, Setoi H, Teraji T. Chryscandin, a novel peptidyl nucleoside antibiotic. II. Structure determination and synthesis. J Antibiot (Tokyo). 1984 Nov;37(11):1284-93. doi: 10.7164/antibiotics.37.1284. PMID: 6549001.
2: Yamashita M, Tsurumi Y, Hosoda J, Komori T, Kohsaka M, Imanaka H. Chryscandin, a novel peptidyl nucleoside antibiotic. I. Taxonomy, fermentation, isolation and characterization. J Antibiot (Tokyo). 1984 Nov;37(11):1279-83. doi: 10.7164/antibiotics.37.1279. PMID: 6549000.
3: Komori T, Sakane K, Setoi H, Kawai Y, Teraji T, Kohsaka M, Imanaka H. Structure activity relationships of synthetic antibiotic analogues of chryscandin. J Antibiot (Tokyo). 1985 Sep;38(9):1182-203. doi: 10.7164/antibiotics.38.1182. PMID: 3840797.
4: Liu M, Arora SK. Structural investigations of mode of action of drugs: structure and conformation of a novel peptidyl nucleoside antibiotic chryscandin hydrochloride pentahydrate. J Antibiot (Tokyo). 2008 May;61(5):322-5. doi: 10.1038/ja.2008.46. PMID: 18653999.
5: Vara J, Perez-Gonzalez JA, Jimenez A. Biosynthesis of puromycin by Streptomyces alboniger: characterization of puromycin N-acetyltransferase. Biochemistry. 1985 Dec 31;24(27):8074-81. doi: 10.1021/bi00348a036. PMID: 4092057.
