MedKoo Cat#: 463714 | Name: ELA23-32

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ELA23-32 is a novel ligand of the apelin receptor (APJ), possessing high affinity for APJ (Ki 4.6 nM) and producing cardiorenal effects in vivo similar to those of ELA.

Chemical Structure

ELA23-32
ELA23-32
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463714

Name: ELA23-32

CAS#: unknown

Chemical Formula: C56H87N15O12

Exact Mass: 1161.6659

Molecular Weight: 1162.41

Elemental Analysis: C, 57.86; H, 7.54; N, 18.08; O, 16.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ELA23-32; ELA2332; ELA23 32;
IUPAC/Chemical Name
((S)-2-aminohexanoyl)-L-prolyl-L-leucyl-L-histidyl-L-seryl-L-arginyl-L-valyl-L-prolyl-L-phenylalanyl-L-proline
InChi Key
VAYNJFRUHYTZOA-BQBSFLCNSA-N
InChi Code
InChI=1S/C56H87N15O12/c1-6-7-17-36(57)52(79)69-23-12-19-42(69)50(77)65-38(26-32(2)3)47(74)64-39(28-35-29-60-31-62-35)48(75)67-41(30-72)49(76)63-37(18-11-22-61-56(58)59)46(73)68-45(33(4)5)54(81)70-24-13-20-43(70)51(78)66-40(27-34-15-9-8-10-16-34)53(80)71-25-14-21-44(71)55(82)83/h8-10,15-16,29,31-33,36-45,72H,6-7,11-14,17-28,30,57H2,1-5H3,(H,60,62)(H,63,76)(H,64,74)(H,65,77)(H,66,78)(H,67,75)(H,68,73)(H,82,83)(H4,58,59,61)/t36-,37-,38-,39-,40-,41-,42-,43-,44-,45-/m0/s1
SMILES Code
O=C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=CC=C4)C(N5[C@@H](CCC5)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCC)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,162.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Trân K, Murza A, Sainsily X, Delile E, Couvineau P, Côté J, Coquerel D, Peloquin M, Auger-Messier M, Bouvier M, Lesur O, Sarret P, Marsault É. Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor. J Med Chem. 2020 Dec 22. doi: 10.1021/acs.jmedchem.0c01547. Epub ahead of print. PMID: 33350824.