Synonym
Chonemorphine; UNII-3AYM0KA3QK
IUPAC/Chemical Name
Pregnane-3,20-diamine, N20,N20-dimethyl-, (3beta,5alpha,20S)-
InChi Key
MJGLREGOLPEPID-GHKGYAFRSA-N
InChi Code
InChI=1S/C23H42N2/c1-15(25(4)5)19-8-9-20-18-7-6-16-14-17(24)10-12-22(16,2)21(18)11-13-23(19,20)3/h15-21H,6-14,24H2,1-5H3/t15-,16-,17-,18-,19+,20-,21-,22-,23+/m0/s1
SMILES Code
C[C@H](N(C)C)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@@H](N)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
346.60
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Shah VC, D'Sa AS, de Souza NJ. Chonemorphine, stigmasterol, and ecdysterone: steroids isolated through bioassay-directed plant screening programs. Steroids. 1989 Mar-May;53(3-5):559-65. doi: 10.1016/0039-128x(89)90031-7. PMID: 2799857.
2: Chatterjee DK, Iyer N, Ganguli BN. Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. Parasitol Res. 1987;74(1):30-3. doi: 10.1007/BF00534928. PMID: 2894025.
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5: GURUSWAMI MN. Chonemorphine: some pharmacological actions. Preliminary report. Indian J Med Sci. 1960 Apr;14:338-43. PMID: 13830383.
6: Jayasinghe UL, Kumarihamya BM, Nadeemb M, Choudhary MI, Atta-Ur-Rahmanb, Weerasooriya A. Iso-N-formyl-5-en-chonemorphine, a steroidal alkaloid from Sarcococca zeylanica. Nat Prod Lett. 2001;15(3):151-5. doi: 10.1080/10575630108041274. PMID: 11858546.
7: Kulkarni AV, Patwardhan AA, Lele U, Malpathak NP. Production of camptothecin in cultures of Chonemorpha grandiflora. Pharmacognosy Res. 2010 Sep;2(5):296-9. doi: 10.4103/0974-8490.72327. PMID: 21589755; PMCID: PMC3093040.
8: Devkota KP, Wansi JD, Lenta BN, Khan S, Choudhary MI, Sewald N. Bioactive steroidal alkaloids from Sarcococca hookeriana. Planta Med. 2010 Jul;76(10):1022-5. doi: 10.1055/s-0029-1240896. Epub 2010 Feb 25. PMID: 20186658.
