Psychorubrin | CAS# | antitumor, antibiotic, antileishmanial

MedKoo Cat#: 412837 | Name: Psychorubrin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Psychorubrin is a biochemical from Psychotria rubra with antitumor, antibiotic, and antileishmanial properties

Chemical Structure

Psychorubrin

CAS# 110271-41-5

Theoretical Analysis

MedKoo Cat#: 412837

Name: Psychorubrin

CAS#: 110271-41-5

Chemical Formula: C13H10O4

Exact Mass: 230.0579

Molecular Weight: 230.22

Elemental Analysis: C, 67.82; H, 4.38; O, 27.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Psychorubrin

IUPAC/Chemical Name

1H-Naphtho(2,3-c)pyran-5,10-dione, 3,4-dihydro-3-hydroxy-

InChi Key

REQISTGTAMMJHO-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H10O4/c14-11-5-9-10(6-17-11)13(16)8-4-2-1-3-7(8)12(9)15/h1-4,11,14H,5-6H2

SMILES Code

O=C(C1=C2COC(O)C1)C3=C(C2=O)C=CC=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 230.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lemos ASO, Campos LM, Melo L, Guedes MCMR, Oliveira LG, Silva TP, Melo RCN, Rocha VN, Aguiar JAK, Apolônio ACM, Scio E, Fabri RL. Antibacterial and Antibiofilm Activities of Psychorubrin, a Pyranonaphthoquinone Isolated From Mitracarpus frigidus (Rubiaceae). Front Microbiol. 2018 Apr 13;9:724. doi: 10.3389/fmicb.2018.00724. PMID: 29706943; PMCID: PMC5908958. 2: Fabri RL, Grazul RM, Carvalho LO, Coimbra ES, Cardoso GM, Souza-Fagundes EM, Silva AD, Scio E. Antitumor, antibiotic and antileishmanial properties of the Pyranonaphthoquinone Psychorubrin from Mitracarpus frigidus. An Acad Bras Cienc. 2012 Dec;84(4):1081-90. doi: 10.1590/s0001-37652012005000064. Epub 2012 Oct 4. PMID: 23037306. 3: Hayashi T, Smith FT, Lee KH. Antitumor agents. 89. Psychorubrin, a new cytotoxic naphthoquinone from Psychotria rubra and its structure-activity relationships. J Med Chem. 1987 Nov;30(11):2005-8. doi: 10.1021/jm00394a013. PMID: 3669007. 4: Fabri RL, Aragão DM, Florêncio JR, Pinto Nde C, Mattos AC, Coelho PM, Castañon MC, Vasconcelos EG, Pinto Pde F, Scio E. Chromatographic fingerprint analysis and effects of the medicinal plant species Mitracarpus frigidus on adult Schistosoma mansoni worms. Biomed Res Int. 2014;2014:941318. doi: 10.1155/2014/941318. Epub 2014 May 8. PMID: 24901000; PMCID: PMC4034476. 5: Fabri RL, Garcia RA, Florêncio JR, de Castro Campos Pinto N, de Oliveira LG, Aguiar JA, Ribeiro A, Scio E. Anti-inflammatory and antioxidative effects of the methanolic extract of the aerial parts of Mitracarpus frigidus in established animal models. J Pharm Pharmacol. 2014 May;66(5):722-32. doi: 10.1111/jphp.12189. Epub 2013 Dec 18. PMID: 24350832. 6: Endale M, Alao JP, Akala HM, Rono NK, Eyase FL, Derese S, Ndakala A, Mbugua M, Walsh DS, Sunnerhagen P, Erdelyi M, Yenesew A. Antiplasmodial quinones from Pentas longiflora and Pentas lanceolata. Planta Med. 2012 Jan;78(1):31-5. doi: 10.1055/s-0031-1280179. Epub 2011 Oct 6. PMID: 21979929.