MedKoo Cat#: 463708 | Name: NEt-C343

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NEt-C343 is a fluorescent RXR antagonist. NEt-C343emits strong fluorescence only when bound to the RXR-LBD. It allows to perform a rapid, simple, and nonhazardous binding assay that does not require bound/free separation and uses a standard plate reader. This assay should be useful for drug discovery as well as for research on endocrine disruptors, functional foods, and natural products.

Chemical Structure

NEt-C343
NEt-C343
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463708

Name: NEt-C343

CAS#: unknown

Chemical Formula: C37H42N4O6

Exact Mass: 638.3104

Molecular Weight: 638.77

Elemental Analysis: C, 69.57; H, 6.63; N, 8.77; O, 15.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NEt-C343; NEtC343; NEt C343;
IUPAC/Chemical Name
6-(ethyl(5-isobutoxy-4-isopropyl-2-(11-oxo-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinoline-10-carboxamido)phenyl)amino)nicotinic acid
InChi Key
ULMIFUYGJNTQBU-UHFFFAOYSA-N
InChi Code
InChI=1S/C37H42N4O6/c1-6-41(32-12-11-24(19-38-32)36(43)44)30-18-31(46-20-21(2)3)27(22(4)5)17-29(30)39-35(42)28-16-25-15-23-9-7-13-40-14-8-10-26(33(23)40)34(25)47-37(28)45/h11-12,15-19,21-22H,6-10,13-14,20H2,1-5H3,(H,39,42)(H,43,44)
SMILES Code
O=C1C(C(NC2=CC(C(C)C)=C(OCC(C)C)C=C2N(CC)C3=NC=C(C(O)=O)C=C3)=O)=CC4=CC(CCC5)=C(N5CCC6)C6=C4O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 638.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yukawa-Takamatsu K, Wang Y, Watanabe M, Takamura Y, Fujihara M, Nakamura- Nakayama M, Yamada S, Kikuzawa S, Makishima M, Kawasaki M, Ito S, Nakano S, Kakuta H. Convenient Retinoid X Receptor Binding Assay Based on Fluorescence Change of the Antagonist NEt-C343. J Med Chem. 2020 Dec 30. doi: 10.1021/acs.jmedchem.0c01883. Epub ahead of print. PMID: 33378197.