MedKoo Cat#: 412813 | Name: Benzestrol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Benzestrol a synthetic nonsteroidal estrogen of the stilbestrol group

Chemical Structure

Benzestrol
CAS#85-95-0

Theoretical Analysis

MedKoo Cat#: 412813

Name: Benzestrol

CAS#: 85-95-0

Chemical Formula: C20H26O2

Exact Mass: 298.1933

Molecular Weight: 298.43

Elemental Analysis: C, 80.50; H, 8.78; O, 10.72

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Synonym
Benzestrol; AI323191; AI3 23191; AI3-23191
IUPAC/Chemical Name
4,4'-(1,2-Diethyl-3-methyl-1,3-propanediyl)bisphenol
InChi Key
DUTFBSAKKUNBAL-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H26O2/c1-4-19(14(3)15-6-10-17(21)11-7-15)20(5-2)16-8-12-18(22)13-9-16/h6-14,19-22H,4-5H2,1-3H3
SMILES Code
CC(C1=CC=C(O)C=C1)C(CC)C(C2=CC=C(O)C=C2)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 298.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: STUART AH, SHUKIS AJ, et al. Synthetic estrogenic compounds; trialkyl derivatives of 1,3-di-(p-hydroxyphenyl)-propane; benzestrol. J Am Chem Soc. 1946 May;68:729-33. doi: 10.1021/ja01209a001. PMID: 21024867. 2: Jandera P, Hájek T, Růžičková M. Retention Models on Core-Shell Columns. J AOAC Int. 2017 Nov 1;100(6):1636-1646. doi: 10.5740/jaoacint.17-0233. Epub 2017 Jul 13. PMID: 28707622. 3: FREGERT S, RORSMAN H. Hypersensitivity to diethylstilbestrol with cross- sensitization to benzestrol. Acta Derm Venereol. 1962;42:290-3. PMID: 13894927. 4: HUFFORD AR. Gastric dysfunction of hypoestrogenic origin; treatment with benzestrol. J Clin Endocrinol Metab. 1946 Dec;6(6):817-22. doi: 10.1210/jcem-6-12-817. PMID: 20288022. 5: Liming FG Jr, Herak JN, Gordy W. Hydrogen addition radicals of stilbestrol, hexestrol, and benzestrol. Proc Natl Acad Sci U S A. 1967 Dec;58(6):2329-35. doi: 10.1073/pnas.58.6.2329. PMID: 4298453; PMCID: PMC223839. 6: Harding FE. ORAL SUBSTITUTION THERAPY WITH BENZESTROL FOR PATIENTS WITH ESTROGEN DEFICIENCY. Calif Med. 1948 Jan;68(1):20-2. PMID: 18731351; PMCID: PMC1643121. 7: Loktionov AS. Issledovanie otveta matki zolotistykh khomiachkov na éstrogennuiu stimuliatsiiu v postnatal'nom ontogeneze [Uterine response of golden hamsters to estrogenic stimulation in postnatal ontogeny]. Ontogenez. 1980;11(5):501-10. Russian. PMID: 6255391. 8: Muzhanovskiĭ EB, Fartushnyĭ AF, Sukhin AP, Sadov AI. Obnaruzhenie nekotorykh abortivnykh sredstv v biologicheskom materiale [The detection of abortion agents in biological material]. Sud Med Ekspert. 1992 Jan-Mar;35(1):24-8. Russian. PMID: 1589888. 9: Loktionov AS, Prianishnikov VA. Avtoradiograficheskoe issledovanie gormonal'noĭ reguliatsii proliferatsii kletok matki zolotistykh khomiachkov v postnatal'nom ontogeneze [Autoradiographic study of hormonal regulation of proliferating golden hamster uterus cells during postnatal ontogeny]. Biull Eksp Biol Med. 1981 Sep;92(9):359-61. Russian. PMID: 6271309. 10: MAKAREVICH-GAL'PERIN LM, USHENKO SN. Sravnitel'naia otsenka deistviia follikulina i oktestrola na uroven' glikogena v pecheni ovariektomirovannykh krys [Comparative evaluation of effects of folliculin and octestrol on glycogen level in the liver in ovariectomized rats]. Probl Endokrinol Gormonoter. 1957 Jul-Aug;3(4):16-21. Russian. PMID: 13505723.