Trisodium DTPA | CAS# 13078-36-9 | chelator

MedKoo Cat#: 412811 | Name: Trisodium DTPA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trisodium DTPA has been used as a chelator for other metals, such as plutonium.

Chemical Structure

Trisodium DTPA

CAS#13078-36-9

Theoretical Analysis

MedKoo Cat#: 412811

Name: Trisodium DTPA

CAS#: 13078-36-9

Chemical Formula: C14H20N3Na3O10

Exact Mass: 459.0842

Molecular Weight: 459.29

Elemental Analysis: C, 36.61; H, 4.39; N, 9.15; Na, 15.02; O, 34.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Trisodium DTPA; PC45; PC-45; PC 45

IUPAC/Chemical Name

dihydrogen trisodium 2,2',2'',2'''-((((carboxylatomethyl)azanediyl)bis(ethane-2,1-diyl))bis(azanetriyl))tetraacetate

InChi Key

HFNVACONKMSOTH-UHFFFAOYSA-K

InChi Code

InChI=1S/C14H23N3O10.3Na/c18-10(19)5-15(1-3-16(6-11(20)21)7-12(22)23)2-4-17(8-13(24)25)9-14(26)27;;;/h1-9H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,26,27);;;/q;3*+1/p-3

SMILES Code

[O-]C(CN(CCN(CC([O-])=O)CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O)=O.[H+].[H+].[Na+].[Na+].[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 459.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang H. Trisodium-[(2-(R)-[(4,4-diphenylcyclohexyl)phosphono- oxymethyl]-diethylenetriaminepentaacetato)(aquo)gadolinium(III): Gadofosveset. 2007 Oct 24 [updated 2008 Jan 3]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641566. 2: Dumit S, Avtandilashvili M, Strom DJ, McComish SL, Tabatadze G, Tolmachev SY. Improved Modeling of Plutonium-DTPA Decorporation. Radiat Res. 2019 Feb;191(2):201-210. doi: 10.1667/RR15188.1. Epub 2018 Dec 19. PMID: 30566387. 3: Ibrahim MA, Hazhirkarzar B, Dublin AB. Gadolinium Magnetic Resonance Imaging. 2020 Jul 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 29494094. 4: Todd DJ, Kay J. Gadolinium-Induced Fibrosis. Annu Rev Med. 2016;67:273-91. doi: 10.1146/annurev-med-063014-124936. PMID: 26768242. 5: Boyken J, Frenzel T, Lohrke J, Jost G, Schütz G, Pietsch H. Impact of Treatment With Chelating Agents Depends on the Stability of Administered GBCAs: A Comparative Study in Rats. Invest Radiol. 2019 Feb;54(2):76-82. doi: 10.1097/RLI.0000000000000522. PMID: 30358694; PMCID: PMC6310454. 6: Shankar GN, Potharaju S, Green CE. Evaluating the toxicity of novel Zn-DTPA tablet formulation in dogs and rats. Drug Dev Res. 2014 Feb;75(1):37-46. doi: 10.1002/ddr.21165. Epub 2013 Dec 26. PMID: 24648048. 7: Hsieh WY, Liu S. Synthesis, characterization, and structures of indium In(DTPA-BA2) and yttrium Y(DTPA-BA2)(CH3OH) complexes (BA = Benzylamine): models for 111In- and 90Y-labeled DTPA-biomolecule conjugates. Inorg Chem. 2004 Sep 20;43(19):6006-14. doi: 10.1021/ic049973g. PMID: 15360250. 8: Ouyang YH, Xu W, Zhou CK, Liu F, Li B, Yan GP, Yang L, Chen S, Jiang C. Porphyrin-containing Gadolinium Complex as a Tumor-targeting Magnetic Resonance Imaging (MRI) Contrast Agent. Curr Drug Deliv. 2018;15(7):972-978. doi: 10.2174/1567201815666180409111005. PMID: 29629659. 9: Lin K, Lloyd-Jones DM, Spottiswoode B, Bi X, Liu Y, Lu B, Xue H, Wang Y, Li D, Carr JC. T1 contrast in the myocardium and blood pool: a quantitative assessment of gadopentetate dimeglumine and gadofosveset trisodium at 1.5 and 3 T. Invest Radiol. 2014 Apr;49(4):243-8. doi: 10.1097/RLI.0000000000000024. PMID: 24473364. 10: Kupczyk PA, Willinek WA, Hadizadeh DR, Traeber F, Gieseke J, Meyer C, Schild HH, Kukuk GM. Abdominal vasculature in dynamic contrast-enhanced liver MRI at 3.0T: an intraindividual comparative study using gadoxetate disodium and gadofosveset trisodium. Magn Reson Imaging. 2015 Dec;33(10):1258-1266. doi: 10.1016/j.mri.2015.08.001. Epub 2015 Aug 10. PMID: 26271178.