FLB-457 | CAS# 107188-66-9 | Biochemical

MedKoo Cat#: 575488 | Name: FLB-457

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FLB-457 is a dopamine antagonist.

Chemical Structure

FLB-457

CAS#107188-66-9

Theoretical Analysis

MedKoo Cat#: 575488

Name: FLB-457

CAS#: 107188-66-9

Chemical Formula: C16H23BrN2O3

Exact Mass: 370.0892

Molecular Weight: 371.27

Elemental Analysis: C, 51.76; H, 6.24; Br, 21.52; N, 7.55; O, 12.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

107188-74-9

Synonym

FLB-457; FLB 457; FLB457; Isoremoxipride

IUPAC/Chemical Name

Benzamide, 5-bromo-N-((1-ethyl-2-pyrrolidinyl)methyl)-2,3-dimethoxy-

InChi Key

QAECXZXKVURFMR-LBPRGKRZSA-N

InChi Code

InChI=1S/C16H23BrN2O3/c1-4-19-7-5-6-12(19)10-18-16(20)13-8-11(17)9-14(21-2)15(13)22-3/h8-9,12H,4-7,10H2,1-3H3,(H,18,20)/t12-/m0/s1

SMILES Code

CCN1CCC[C@H]1CNC(=O)c2cc(Br)cc(OC)c2OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 371.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Narendran R, Jedema HP, Lopresti BJ, Mason NS, Gurnsey K, Ruszkiewicz J, Chen CM, Deuitch L, Frankle WG, Bradberry CW. Imaging dopamine transmission in the frontal cortex: a simultaneous microdialysis and [11C]FLB 457 PET study. Mol Psychiatry. 2014 Mar;19(3):302-10. doi: 10.1038/mp.2013.9. Epub 2013 Feb 26. Erratum in: Mol Psychiatry. 2014 Mar;19(3):399. PMID: 23439486; PMCID: PMC3706503. 2. Narendran R, Mason NS, Chen CM, Himes M, Keating P, May MA, Rabiner EA, Laruelle M, Mathis CA, Frankle WG. Evaluation of dopamine D₂/₃ specific binding in the cerebellum for the positron emission tomography radiotracer [¹¹C]FLB 457: implications for measuring cortical dopamine release. Synapse. 2011 Oct;65(10):991-7. doi: 10.1002/syn.20926. Epub 2011 Apr 26. PMID: 21360596; PMCID: PMC3135684.