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MedKoo Cat#: 575480 | Name: FK-143

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FK-143 is a 5-alpha reductase inhibitor.

Chemical Structure

FK-143
FK-143
CAS#163136-03-6

Theoretical Analysis

MedKoo Cat#: 575480

Name: FK-143

CAS#: 163136-03-6

Chemical Formula: C40H44N2O3

Exact Mass: 600.3352

Molecular Weight: 600.80

Elemental Analysis: C, 79.97; H, 7.38; N, 4.66; O, 7.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
FK-143; FK 143; FK143
IUPAC/Chemical Name
4-(3-(3-((bis(4-isobutylphenyl)methyl)amino)benzoyl)-1H-indol-1-yl)butanoic acid
InChi Key
LACIBZRFAYFTOV-UHFFFAOYSA-N
InChi Code
InChI=1S/C40H44N2O3/c1-27(2)23-29-14-18-31(19-15-29)39(32-20-16-30(17-21-32)24-28(3)4)41-34-10-7-9-33(25-34)40(45)36-26-42(22-8-13-38(43)44)37-12-6-5-11-35(36)37/h5-7,9-12,14-21,25-28,39,41H,8,13,22-24H2,1-4H3,(H,43,44)
SMILES Code
CC(C)Cc1ccc(cc1)C(Nc2cccc(c2)C(=O)c3cn(CCCC(=O)O)c4ccccc34)c5ccc(CC(C)C)cc5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 600.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Robaire B, Henderson NA. Actions of 5alpha-reductase inhibitors on the epididymis. Mol Cell Endocrinol. 2006 May 16;250(1-2):190-5. doi: 10.1016/j.mce.2005.12.044. Epub 2006 Feb 14. PMID: 16476520. 2. Kojo H, Nakayama O, Hirosumi J, Chida N, Notsu Y, Okuhara M. Novel steroid 5 alpha-reductase inhibitor FK143: its dual inhibition against the two isozymes and its effect on transcription of the isozyme genes. Mol Pharmacol. 1995 Sep;48(3):401-6. PMID: 7565619. 3. Maruyama S, Nagasue N, Dhar DK, Yamanoi A, El-Assal ON, Satoh K, Okita K. Preventive effect of FK143, a 5alpha-reductase inhibitor, on chemical hepatocarcinogenesis in rats. Clin Cancer Res. 2001 Jul;7(7):2096-104. PMID: 11448929.

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