FR-66973 | CAS# 113202-60-1 | Biochemical

MedKoo Cat#: 575470 | Name: FR-66973

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FR-66973 is an antitumor antibiotic that is more potent against B16 melanoma and P388 leukemia than mitomycin C.

Chemical Structure

FR-66973

CAS#113202-60-1

Theoretical Analysis

MedKoo Cat#: 575470

Name: FR-66973

CAS#: 113202-60-1

Chemical Formula: C20H21N3O9

Exact Mass: 447.1278

Molecular Weight: 447.40

Elemental Analysis: C, 53.69; H, 4.73; N, 9.39; O, 32.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

FK973; FK 973; FK-973; FR 66973; FR66973; FR-66973

IUPAC/Chemical Name

3,9-Epoxy-3H-azirino(2,3-c)(1)benzazocine-5-carboxaldehyde, 1-acetyl-7,9-bis(acetyloxy)-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,9,9a-hexahydro-

InChi Key

FBXPCVIKIBWXAE-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H21N3O9/c1-9(25)23-15-6-22-14-4-12(7-24)5-16(30-10(2)26)17(14)13(8-29-19(21)28)20(32-22,18(15)23)31-11(3)27/h4-5,7,13,15,18H,6,8H2,1-3H3,(H2,21,28)

SMILES Code

CC(=O)Oc1cc(C=O)cc2N3CC4C(N4C(=O)C)C(OC(=O)C)(O3)C(COC(=O)N)c12

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 447.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Shimizu K, Yamada M, Mabuchi E, Matsui Y, Tamura K, Moriuchi S, Park K, Mogami H. [Antitumor efficacy of FK 973 on malignant glioma cells]. Gan To Kagaku Ryoho. 1989 Jul;16(7):2367-72. Japanese. PMID: 2751317. 2. Horiuchi N, Nakagawa K, Sasaki Y, Minato K, Fujiwara Y, Nezu K, Ohe Y, Saijo N. In vitro antitumor activity of mitomycin C derivative (RM-49) and new anticancer antibiotics (FK973) against lung cancer cell lines determined by tetrazolium dye (MTT) assay. Cancer Chemother Pharmacol. 1988;22(3):246-50. doi: 10.1007/BF00273419. PMID: 2842080.