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MedKoo Cat#: 575467 | Name: FK-664

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FK-664 is a cardiotonic agent and positive inotropic agent. FK664 has positive inotropic and chronotropic effects on the heart, due to an enhancement of transsarcolemmal calcium influx through the low threshold, dihydropyridine insensitive Ca2+ channel population. FK664 may be a potent cardiotonic agent for the treatment of heart failure.

Chemical Structure

FK-664
FK-664
CAS#94936-90-0

Theoretical Analysis

MedKoo Cat#: 575467

Name: FK-664

CAS#: 94936-90-0

Chemical Formula: C24H29N3O3

Exact Mass: 407.2209

Molecular Weight: 407.51

Elemental Analysis: C, 70.74; H, 7.17; N, 10.31; O, 11.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
FK-664; FK 664; FK664;
IUPAC/Chemical Name
2(1H)-Pyrimidinone, 6-(3,4-dimethoxyphenyl)-1-ethyl-3,4-dihydro-3-methyl-4-((2,4,6-trimethylphenyl)imino)-
InChi Key
OYGHXRNCHYRYRR-YYDJUVGSSA-N
InChi Code
InChI=1S/C24H29N3O3/c1-8-27-19(18-9-10-20(29-6)21(13-18)30-7)14-22(26(5)24(27)28)25-23-16(3)11-15(2)12-17(23)4/h9-14H,8H2,1-7H3/b25-22+
SMILES Code
CCN1C(=O)N(C)\C(=N\c2c(C)cc(C)cc2C)\C=C1c3ccc(OC)c(OC)c3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 407.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kodama I, Anno T, Sudo Y, Satake N, Shibata S. Electrophysiological effects of FK664, a new cardiotonic agent, on preparations from guinea pig ventricle and from rabbit sino-atrial node. Cardiovasc Res. 1989 May;23(5):369-77. doi: 10.1093/cvr/23.5.369. PMID: 2558795. 2: Sudo Y, Takai M, Esumi K. Improved heart failure protection by FK664, a novel positive inotropic agent, in dog heart-lung preparations. Life Sci. 1992;51(6):PL41-6. doi: 10.1016/0024-3205(92)90417-n. PMID: 1386131. 3: Miyamae A, Kitamura S, Tada T, Koda S, Yasuda T. X-ray structural studies and physicochemical characterization of (E)-6-(3,4-dimethoxyphenyl)-1-ethyl-4-mesitylimino-3-methyl- 3,4-dihydro-2(1H)-pyrimidinone polymorphs. J Pharm Sci. 1991 Oct;80(10):995-1000. doi: 10.1002/jps.2600801018. PMID: 1784011. 4: Sudo Y, Esumi K. The effect of FK664, a new cardiovascular drug, on systemic capacitance vessels in anesthetized dogs. Life Sci. 1992;51(25):PL261-5. doi: 10.1016/0024-3205(92)90120-e. PMID: 1453874.