Synonym
Chinoin 123; CH123; CH-123; CH 123
IUPAC/Chemical Name
3-(Ethoxycarbonyl)-6,7,8,9-tetrahydro-6-methyl-4-oxo-4H-pyrido(1,2-a)pyrimidine-9-acetic acid
InChi Key
IRGLQUMAHASUTG-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H18N2O5/c1-3-21-14(20)10-7-15-12-9(6-11(17)18)5-4-8(2)16(12)13(10)19/h7-9H,3-6H2,1-2H3,(H,17,18)
SMILES Code
O=C(O)CC1CCC(C)N(C1=NC=C2C(OCC)=O)C2=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
294.31
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tóth K, Vargay Z, Lévai F, Várkonyi P. A Chinoin-123 farmakokinetikája patkányban, kutyában és emberben [Pharmacokinetics of Chinoin-123 in rats, dogs and humans]. Acta Pharm Hung. 1989;59 Suppl 1:6-11. Hungarian. PMID: 2641636.
2: Virág S, Vértesi C, Welner I. Combined vessel injuring action of adjuvant arthritis and cholesterol diet. (III. Action of Chinoin-123 on a new model of experimental atherosclerosis of rat). Ther Hung. 1978;26(4):171-3. PMID: 375458.
3: Bédi J, Blaskó G, Pálos LA. The effect of some pyrimido-pyrimidine derivatives on blood coagulation and platelet aggregation. Arzneimittelforschung. 1979;29(9):1405-8. PMID: 583250.
4: Szentmiklósi P, Marton S, Kovács M, Gyarmati L. The absorption and excretion rates of a new pyrido[1,2-a] pyrimidine derivative (Chinoin 123) in rats. Pharmazie. 1979;34(9):551-6. PMID: 542489.
5: Hesz A, Boda L, Schneider F, Lusztig G, Virág S. Effect of Chinoin-123 on the permeability of the aortic wall in rabbits kept on a hyperlipemic diet (Investigation of aortic wall permeability by Evans-blue method). Ther Hung. 1978;26(4):174-7. PMID: 751273.
6: Hesz A, Boda L, Schneider F, Lusztig G, Virág S. Effect of Chinoin-123 on aortic wall permeability of rabbits given forced hyperlipemic diet (distribution of labelled human albumin in thoracic segment of the aorta). Ther Hung. 1978;26(4):178-9. PMID: 751274.
7: Csonka E, Takács E, Büki K, Bauer P, Virág S. A chinoin-123 antiaterogén hatású vegyület vizsgálata érszövettenyészetben [Chinoin-132, an anti- atherogenic substance, studied in vascular tissue cultures]. Morphol Igazsagugyi Orv Sz. 1986 Jul;26(3):191-5. Hungarian. PMID: 3736572.
8: Hermecz I, Mészáros Z, Vasvári-Debreczy L, Horváth A, Virág S, Sipos J. Nitrogen bridgehead compounds. Part 7: Synthesis of anti-atherosclerotic pyrido[1,2-a]pyrimidines. Arzneimittelforschung. 1979;29(12):1833-5. PMID: 546421.
9: Ecsedi GG, Virág S, Hidvégi EJ. Effect of CH-1243, a pyrido (1,2-a) pyrimidine derivative on the elevated activity of lysosomal enzymes of rabbit aorta and liver in experimental atherosclerosis. Atherosclerosis. 1981 May;39(2):183-90. doi: 10.1016/0021-9150(81)90068-x. PMID: 7247998.
