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MedKoo Cat#: 412779 | Name: Chinoin 127

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chinoin 127 is a biochemical

Chemical Structure

Chinoin 127
Chinoin 127
CAS#54606-29-0

Theoretical Analysis

MedKoo Cat#: 412779

Name: Chinoin 127

CAS#: 54606-29-0

Chemical Formula: C11H17N3O2

Exact Mass: 223.1321

Molecular Weight: 223.28

Elemental Analysis: C, 59.17; H, 7.67; N, 18.82; O, 14.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Chinoin 127; CH127; CH-127; CH 127
IUPAC/Chemical Name
4H-Pyrido(1,2-a)pyrimidine-3-carboxamide, 1,6,7,8,9,9a-hexahydro-1,6-dimethyl-4-oxo-
InChi Key
PDYZVPFJLHCRGG-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H17N3O2/c1-7-4-3-5-9-13(2)6-8(10(12)15)11(16)14(7)9/h6-7,9H,3-5H2,1-2H3,(H2,12,15)
SMILES Code
O=C(C1=CN(C)C(CCCC2C)N2C1=O)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 223.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kalmár L, Láng I, Gonzelez-Cabello P, Gergely P, Fehér J. Effects on immune reactions of non-steroidal anti-inflammatory drugs and of two new pyrido- pyrimidine derivatives (CHINOIN 127 and CHINOIN 105). Acta Med Hung. 1986;43(3):255-63. PMID: 3295745. 2: Bernus I, Tóth A, Kálóy K, Takácsy TE. Analytical studies on the hydrolysis of Chinoin-102 and Chinoin-127, candidate compounds for stability studies. J Pharm Biomed Anal. 1985;3(5):405-15. doi: 10.1016/0731-7085(85)80054-6. PMID: 16867652. 3: Kapui Z, Boér K, Hermecz I, Gyíres K. The mechanism of cytoprotective effect of CHINOIN-127. Acta Physiol Hung. 1992;80(1-4):237-45. PMID: 1345193. 4: Gergelyné-Zobin A, Szász G, Hermecz I. Pirido-pirimidin-karboxamid (CHINOIN-127) dehidrogénezödéssel járó bomlásáról [Dehydrogenation accompanied decomposition of pyrido-pyrimidine carboxamide (CHINOIN-127)]. Acta Pharm Hung. 1983 Sep;53(5):222-8. Hungarian. PMID: 6605660. 5: Kovács Z, Kapui Z, Cser I, Hermecz I, Rózsa I, Blaskó G. The gastroprotective effect of CHINOIN-127 on indomethacin induced gastric ulcer in rats. Acta Physiol Hung. 1990;75 Suppl:185-6. PMID: 2115229. 6: Knoll J, Gyires K, Mészáros Z. 1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido [1,2-a] pyrimidine-3-carboxamide (Chinoin-127), a potent non-narcotic analgesic and antiinflammatory agent. Arzneimittelforschung. 1979;29(5):766-73. PMID: 315232. 7: Knoll J, Gyires K, Hermecz I. 1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido(1,2-a)- pyrimidine-3-carboxamide (Ch-127) protects against the intestinal damage in rats caused by two weeks' daily administration of indomethacin. Drugs Exp Clin Res. 1987;13(5):253-8. PMID: 3500028. 8: Rózsa I, Kapui Z, Szécsi T, Hermecz I, Blaskó G. Synthesis of prostacyclin and thromboxane A2 by rat gastric mucosa. Comparison of 1,6-dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido (1,1-a)-pyrimidine-3-carboxamide and cimetidine. Arzneimittelforschung. 1989 Jun;39(6):686-9. PMID: 2673252.