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MedKoo Cat#: 412776 | Name: Cgs 27830

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cgs 27830 is an Endothelin Receptor Antagonist.

Chemical Structure

Cgs 27830
Cgs 27830
CAS#155485-56-6

Theoretical Analysis

MedKoo Cat#: 412776

Name: Cgs 27830

CAS#: 155485-56-6

Chemical Formula: C32H30N4O11

Exact Mass: 646.1911

Molecular Weight: 646.60

Elemental Analysis: C, 59.44; H, 4.68; N, 8.66; O, 27.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Cgs 27830; Cgs-27830; Cgs27830
IUPAC/Chemical Name
meso-1,4-Dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridine carboxylic acid anhydride
InChi Key
PZNZOWSLQRURNA-HNRBIFIRSA-N
InChi Code
InChI=1S/C32H30N4O11/c1-15-23(29(37)45-5)27(19-9-7-11-21(13-19)35(41)42)25(17(3)33-15)31(39)47-32(40)26-18(4)34-16(2)24(30(38)46-6)28(26)20-10-8-12-22(14-20)36(43)44/h7-14,27-28,33-34H,1-6H3/t27-,28+
SMILES Code
O=C(OC(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC=CC([N+]([O-])=O)=C2)=O)C3=C(C)NC(C)=C(C(OC)=O)[C@H]3C4=CC=CC([N+]([O-])=O)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 646.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mateo AO, de Artiñano MA. Effect of high extracellular Ca(2+) levels in spontaneously hypertensive rat aorta. Eur J Pharmacol. 2001 Dec 7;432(2-3):177-85. doi: 10.1016/s0014-2999(01)01415-7. PMID: 11740954. 2: Chin MH, Cioffi CL, Garay M, Neale RF, Shetty SS, DelGrande D, Mugrage B, Sills MA, Lipson KE. The unusual binding properties of the endothelin receptor antagonist CGS 27830 distinguishes receptor/agonist interactions. J Pharmacol Exp Ther. 1996 Jan;276(1):74-83. PMID: 8558459. 3: Ivy DD, Kinsella JP, Abman SH. Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation. J Clin Invest. 1994 May;93(5):2141-8. doi: 10.1172/JCI117210. PMID: 8182146; PMCID: PMC294348.