Synonym
Cgs 18102A (HCl); Cgs18102A; Cgs18102A
IUPAC/Chemical Name
2H-(1)Benzopyrano(3,4-b)pyridine, 1,3,4,4a,5,10b-hexahydro-10-methoxy-4-propyl-, hydrochloride, trans-
InChi Key
IIARBXRSECAIPI-KZCZEQIWSA-N
InChi Code
InChI=1S/C16H23NO2.ClH/c1-3-9-17-10-5-6-12-13(17)11-19-15-8-4-7-14(18-2)16(12)15;/h4,7-8,12-13H,3,5-6,9-11H2,1-2H3;1H/t12-,13+;/m1./s1
SMILES Code
CCCN1CCC[C@]2([H])[C@]1([H])COC3=CC=CC(OC)=C32.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
297.82
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sills MA, Bennett DA, Lovell RA, Liebman JM, Wood PL, Glaeser BS, Williams M, Hutchison AJ. CGS 18102A, a benzopyranopyridine anxiolytic with 5-HT1 agonist and 5-HT2 antagonist properties. Prog Clin Biol Res. 1990;361:469-75. PMID: 1981265.
2: Kleven MS, Assié MB, Koek W. Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT(2A/2C) antagonist anxiolytics. II. Drug discrimination and behavioral observation studies in rats. J Pharmacol Exp Ther. 1997 Aug;282(2):747-59. PMID: 9262338.
3: Kleven MS, Koek W. Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon. J Pharmacol Exp Ther. 1996 Feb;276(2):388-97. PMID: 8632301.
4: Leal M, Hayes MJ, Powell ML. Quantitative determination of CGS 18102A, a new anxiolytic, in human plasma using capillary gas chromatography/mass spectrometry. Biomed Chromatogr. 1992 Sep-Oct;6(5):244-7. doi: 10.1002/bmc.1130060509. PMID: 1361157.
5: Stelling MS, Maniara WM, Powell ML. A quantitative analytical method for the determination of a new anxiolytic (CGS 19480A) in human plasma using high performance liquid chromatography. Biomed Chromatogr. 1994 Nov-Dec;8(6):288-90. doi: 10.1002/bmc.1130080607. PMID: 7888731.
