Pentopril | CAS# 82924-03-6 | Enzyme Inhibitor (Angiotensin-Converting)

MedKoo Cat#: 412746 | Name: Pentopril

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pentopril is an Enzyme Inhibitor (Angiotensin-Converting)

Chemical Structure

Pentopril

CAS# 82924-03-6

Theoretical Analysis

MedKoo Cat#: 412746

Name: Pentopril

CAS#: 82924-03-6

Chemical Formula: C18H23NO5

Exact Mass: 333.1576

Molecular Weight: 333.38

Elemental Analysis: C, 64.85; H, 6.95; N, 4.20; O, 23.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Pentopril; CGS13945; CGS-13945; CGS 13945

IUPAC/Chemical Name

(S)-1-((2R,4R)-5-ethoxy-2,4-dimethyl-5-oxopentanoyl)indoline-2-carboxylic acid

InChi Key

NVXFXLSOGLFXKQ-JMSVASOKSA-N

InChi Code

InChI=1S/C18H23NO5/c1-4-24-18(23)12(3)9-11(2)16(20)19-14-8-6-5-7-13(14)10-15(19)17(21)22/h5-8,11-12,15H,4,9-10H2,1-3H3,(H,21,22)/t11-,12-,15+/m1/s1

SMILES Code

CCOC([C@@H](C[C@H](C(N1[C@H](C(O)=O)Cc2c1cccc2)=O)C)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 333.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rakhit A, Kochak GM, Tipnis V, Hurley ME. Inhibition of renal clearance of furosemide by pentopril, an angiotensin-converting enzyme inhibitor. Clin Pharmacol Ther. 1987 May;41(5):580-6. doi: 10.1038/clpt.1987.75. PMID: 3032491. 2: Song JC, White CM. Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet. 2002;41(3):207-24. doi: 10.2165/00003088-200241030-00005. PMID: 11929321. 3: Stefan RI, Staden JF, Bala C, Aboul-Enein HY. On-line assay of the S-enantiomers of enalapril, ramipril and pentopril using a sequential injection analysis/amperometric biosensor system. J Pharm Biomed Anal. 2004 Nov 19;36(4):889-92. doi: 10.1016/j.jpba.2004.08.017. PMID: 15533685. 4: Rakhit A, Kochak GM, Tipnis V, Radensky P, Hurley ME, Williams R. Pharmacokinetics of pentopril in the elderly. Br J Clin Pharmacol. 1987 Sep;24(3):351-7. doi: 10.1111/j.1365-2125.1987.tb03180.x. PMID: 2822067; PMCID: PMC1386257. 5: Bird HA, Le Gallez P, Dixon JS, Catalano MA, Traficante A, Liauw LA, Sussman H, Rotman H, Wright V. A clinical and biochemical assessment of a nonthiol ACE inhibitor (pentopril; CGS-13945) in active rheumatoid arthritis. J Rheumatol. 1990 May;17(5):603-8. PMID: 2359068. 6: Aboul-Enein HY, Stefan RI, Radu GL. Biosensor for enantioselective analysis of S-cilazapril, S-trandolapril, and S-pentopril. Pharm Dev Technol. 1999 May;4(2):251-5. doi: 10.1081/pdt-100101359. PMID: 10231886. 7: Rakhit A, Radensky P, Szerlip HM, Kochak GM, Audet PR, Hurley ME, Feldman GM. Effect of renal impairment on disposition of pentopril and its active metabolite. Clin Pharmacol Ther. 1988 Jul;44(1):39-48. doi: 10.1038/clpt.1988.110. PMID: 3391004. 8: Kochak GM, Rakhit A, Thompson TN, Hurley ME. Pentopril-cimetidine interaction caused by a reduction in hepatic blood flow. J Clin Pharmacol. 1988 Mar;28(3):222-7. doi: 10.1002/j.1552-4604.1988.tb03136.x. PMID: 3360970. 9: Rakhit A, Hurley ME, Tipnis V, Coleman J, Rommel A, Brunner HR. Pharmacokinetics and pharmacodynamics of pentopril, a new angiotensin- converting-enzyme inhibitor in humans. J Clin Pharmacol. 1986 Mar;26(3):156-64. doi: 10.1002/j.1552-4604.1986.tb02927.x. PMID: 3007583. 10: Rakhit A, Kochak G, Dotson R, Tipnis V. Disposition of pentopril, a new orally active angiotensin-converting enzyme inhibitor, and its active metabolite in rats. J Pharm Sci. 1985 Sep;74(9):947-52. doi: 10.1002/jps.2600740908. PMID: 2999376.