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MedKoo Cat#: 575428 | Name: Melperone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Melperone is a butyrophenone neuroleptic and an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine.

Chemical Structure

Melperone
Melperone
CAS#3575-80-2

Theoretical Analysis

MedKoo Cat#: 575428

Name: Melperone

CAS#: 3575-80-2

Chemical Formula: C16H22FNO

Exact Mass: 263.1685

Molecular Weight: 263.36

Elemental Analysis: C, 72.97; H, 8.42; F, 7.21; N, 5.32; O, 6.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Bunil; FG 5111; Melperone
IUPAC/Chemical Name
4'-Fluoro-4-(4-methylpiperidino)butyrophenone
InChi Key
DKMFBWQBDIGMHM-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H22FNO/c1-13-8-11-18(12-9-13)10-2-3-16(19)14-4-6-15(17)7-5-14/h4-7,13H,2-3,8-12H2,1H3
SMILES Code
CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 263.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Grözinger M, Dragicevic A, Hiemke C, Shams M, Müller MJ, Härtter S. Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine. Pharmacopsychiatry. 2003 Jan;36(1):3-6. doi: 10.1055/s-2003-38084. PMID: 12649767. 2. Hefner G, Unterecker S, Shams ME, Wolf M, Falter T, Haen E, Hiemke C. Melperone but not bisoprolol or metoprolol is a clinically relevant inhibitor of CYP2D6: evidence from a therapeutic drug monitoring survey. J Neural Transm (Vienna). 2015 Nov;122(11):1609-17. doi: 10.1007/s00702-015-1403-7. Epub 2015 May 5. PMID: 25940834.