SP10 | CAS#882157-88-2 | SARS-CoV Spike (S) protein inhibitor

MedKoo Cat#: 463661 | Name: SP10

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SP10 is a novel highly potent inhibitor of SARS-CoV Spike (S) protein and ACE2 interaction.

Chemical Structure

SP10

CAS#882157-88-2

Theoretical Analysis

MedKoo Cat#: 463661

Name: SP10

CAS#: 882157-88-2

Chemical Formula: C56H94N14O20S

Exact Mass: 1314.6490

Molecular Weight: 1315.51

Elemental Analysis: C, 51.13; H, 7.20; N, 14.91; O, 24.32; S, 2.44

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 500.00	2 Weeks

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Related CAS #

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Synonym

SP10; SP 10; SP-10; SP-10 (residues 668–679); SP10 (residues 668–679); SP 10 (residues 668–679);

IUPAC/Chemical Name

L-seryl-L-threonyl-L-seryl-L-glutaminyl-L-lysyl-L-seryl-L-isoleucyl-L-valyl-L-alanyl-L-tyrosyl-L-threonyl-L-methionine

InChi Key

RBLTWUZIFRZOSV-SQWMWQRLSA-N

InChi Code

InChI=1S/C56H94N14O20S/c1-9-27(4)42(53(86)67-41(26(2)3)52(85)60-28(5)45(78)64-37(22-31-13-15-32(76)16-14-31)49(82)70-44(30(7)75)54(87)63-36(56(89)90)19-21-91-8)68-51(84)39(25-73)65-47(80)34(12-10-11-20-57)61-48(81)35(17-18-40(59)77)62-50(83)38(24-72)66-55(88)43(29(6)74)69-46(79)33(58)23-71/h13-16,26-30,33-39,41-44,71-76H,9-12,17-25,57-58H2,1-8H3,(H2,59,77)(H,60,85)(H,61,81)(H,62,83)(H,63,87)(H,64,78)(H,65,80)(H,66,88)(H,67,86)(H,68,84)(H,69,79)(H,70,82)(H,89,90)/t27-,28-,29+,30+,33-,34-,35-,36-,37-,38-,39-,41-,42-,43-,44-/m0/s1

SMILES Code

O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCSC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

SP10 is a small peptide derived from S protein with an IC50 value of 1.88 nM for blocks the interaction between S protein and ACE2.

In vitro activity:

SP10 has therapeutic potential for the treatment of SARS-CoV infections. SP10 significantly blocked the interaction between S protein and ACE2 by biotinylated enzyme-linked immunosorbent assay with an IC50 value of 1.88 +/- 0.52 nmol. SP10 blocked both binding of the S protein and infectivity of S protein-pseudotyped retrovirus to Vero E6 cells. Reference: Antiviral Res. 2006 Feb;69(2):70-6. https://pubmed.ncbi.nlm.nih.gov/16337697/

In vivo activity:

To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 1,315.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Ho TY, Wu SL, Chen JC, Wei YC, Cheng SE, Chang YH, Liu HJ, Hsiang CY. Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 2006 Feb;69(2):70-6. doi: 10.1016/j.antiviral.2005.10.005. Epub 2005 Nov 28. PMID: 16337697; PMCID: PMC7114127.

In vitro protocol:

In vivo protocol:

To be determined