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MedKoo Cat#: 535793 | Name: Clofenamic acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clofenamic acid is a bioactive chemical.

Chemical Structure

Clofenamic acid
Clofenamic acid
CAS#4295-55-0

Theoretical Analysis

MedKoo Cat#: 535793

Name: Clofenamic acid

CAS#: 4295-55-0

Chemical Formula: C13H9Cl2NO2

Exact Mass: 281.0010

Molecular Weight: 282.12

Elemental Analysis: C, 55.35; H, 3.22; Cl, 25.13; N, 4.96; O, 11.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Clofenamic acid
IUPAC/Chemical Name
N-(2,3-Dichlorophenyl)anthranilic acid
InChi Key
JONFYSWOLCTYFK-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H9Cl2NO2/c14-9-5-3-7-11(12(9)15)16-10-6-2-1-4-8(10)13(17)18/h1-7,16H,(H,17,18)
SMILES Code
O=C(O)C1=CC=CC=C1NC2=CC=CC(Cl)=C2Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 282.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Huang Y, Yan J, Li Q, Li J, Gong S, Zhou H, Gan J, Jiang H, Jia GF, Luo C, Yang CG. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84. doi: 10.1093/nar/gku1276. Epub 2014 Dec 1. PMID: 25452335; PMCID: PMC4288171. 2: Eleftheriou CG, Cehajic-Kapetanovic J, Martial FP, Milosavljevic N, Bedford RA, Lucas RJ. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. PMID: 28659709; PMCID: PMC5479694. 3: Delgado-Enciso I, Soriano-Hernández AD, Rodriguez-Hernandez A, Galvan-Salazar HR, Montes-Galindo DA, Martinez-Martinez R, Valdez-Velazquez LL, Gonzalez- Alvarez R, Espinoza-Gómez F, Newton-Sanchez OA, Lara-Esqueda A, Guzman-Esquivel J. Histological changes caused by meclofenamic acid in androgen-independent prostate cancer tumors: evaluation in a mouse model. Int Braz J Urol. 2015 Sep- Oct;41(5):1002-7. doi: 10.1590/S1677-5538.IBJU.2013.00186. PMID: 26689527; PMCID: PMC4756978. 4: Izzo V, Pagnoni B, Rigoli M. Recent acquisitions in pain therapy: meclofenamic acid. Clin J Pain. 1991;7 Suppl 1:S49-53. PMID: 1810521. 5: Gooneratne AD, Hartmann PE, Barker I. Influence of meclofenamic acid on the initiation of parturition and lactation in the sow. J Reprod Fertil. 1982 May;65(1):157-62. doi: 10.1530/jrf.0.0650157. PMID: 7077592. 6: Soriano-Hernández AD, Galvan-Salazar HR, Montes-Galindo DA, Rodriguez- Hernandez A, Martinez-Martinez R, Guzman-Esquivel J, Valdez-Velazquez LL, Baltazar-Rodriguez LM, Espinoza-Gómez F, Rojas-Martinez A, Ortiz-Lopez R, Gonzalez-Alvarez R, Delgado-Enciso I. Antitumor effect of meclofenamic acid on human androgen-independent prostate cancer: a preclinical evaluation. Int Urol Nephrol. 2012 Apr;44(2):471-7. doi: 10.1007/s11255-011-0012-0. Epub 2011 Jun 10. PMID: 21660425. 7: Schober W, Kehlbach R, Gebert R, Wiskirchen J, Rodegerdts E, Claussen CD, Duda SH. Meclofenamic acid for inhibition of human vascular smooth muscle cell proliferation and migration: an in vitro study. Cardiovasc Intervent Radiol. 2002 Jan-Feb;25(1):57-63. doi: 10.1007/s00270-001-0077-8. Epub 2002 Jan 17. PMID: 11907776. 8: Wilsher S, Kölling M, Allen WR. Meclofenamic acid extends donor-recipient asynchrony in equine embryo transfer. Equine Vet J. 2006 Sep;38(5):428-32. doi: 10.2746/042516406778400547. PMID: 16986603. 9: Ning N, Wen Y, Li Y, Li J. Meclofenamic acid blocks the gap junction communication between the retinal pigment epithelial cells. Hum Exp Toxicol. 2013 Nov;32(11):1164-9. doi: 10.1177/0960327112472997. Epub 2013 Apr 12. PMID: 23584353. 10: Kovala-Demertzi D, Dokorou V, Primikiri A, Vargas R, Silvestru C, Russo U, Demertzis MA. Organotin meclofenamic complexes: Synthesis, crystal structures and antiproliferative activity of the first complexes of meclofenamic acid - novel anti-tuberculosis agents. J Inorg Biochem. 2009 May;103(5):738-44. doi: 10.1016/j.jinorgbio.2009.01.014. Epub 2009 Jan 27. PMID: 19237201.

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