Synonym
QTC-4-MeOBnE; QTC4-MeOBnE; QTC 4-MeOBnE; QTC-4MeOBnE; QTC-4 MeOBnE; QTC4MeOBnE; QTC 4 MeOBnE;
IUPAC/Chemical Name
1-(7-chloroquinolin-4-yl)-N-(4-methoxybenzyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide
InChi Key
SVJJXBAHZZVFPI-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H18ClN5O2/c1-13-20(21(28)24-12-14-3-6-16(29-2)7-4-14)25-26-27(13)19-9-10-23-18-11-15(22)5-8-17(18)19/h3-11H,12H2,1-2H3,(H,24,28)
SMILES Code
O=C(C1=C(C)N(C2=CC=NC3=CC(Cl)=CC=C23)N=N1)NCC4=CC=C(OC)C=C4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
407.86
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Fronza MG, Baldinotti R, Sacramento M, Gutierres J, Carvalho FB, Fernandes MDC, Sousa FSS, Seixas FK, Collares T, Alves D, Pratico D, Savegnago L. Effect of QTC-4-MeOBnE Treatment on Memory, Neurodegeneration, and Neurogenesis in a Streptozotocin-Induced Mouse Model of Alzheimer's Disease. ACS Chem Neurosci. 2020 Dec 14. doi: 10.1021/acschemneuro.0c00615. Epub ahead of print. PMID: 33315382.
2: Fronza MG, Baldinotti R, Fetter J, Sacramento M, Sousa FSS, Seixas FK, Collares T, Alves D, Praticò D, Savegnago L. QTC-4-MeOBnE Rescues Scopolamine- Induced Memory Deficits in Mice by Targeting Oxidative Stress, Neuronal Plasticity, and Apoptosis. ACS Chem Neurosci. 2020 May 6;11(9):1259-1269. doi: 10.1021/acschemneuro.9b00661. Epub 2020 Apr 13. PMID: 32227985.
3: Fronza MG, Baldinotti R, Martins MC, Goldani B, Dalberto BT, Kremer FS, Begnini K, Pinto LDS, Lenardão EJ, Seixas FK, Collares T, Alves D, Savegnago L. Rational design, cognition and neuropathology evaluation of QTC-4-MeOBnE in a streptozotocin-induced mouse model of sporadic Alzheimer's disease. Sci Rep. 2019 May 13;9(1):7276. doi: 10.1038/s41598-019-43532-9. PMID: 31086208; PMCID: PMC6513848.
