Eclitasertib, also known as DNL-758 and SAR-443122, is a receptor-interacting serine/ threonine protein (RIP-1) kinase inhibitor. Eclitasertib disrupts RIPK1-mediated signaling, and may attenuate inflammation and the resulting tissue damage. RIPK1, a signaling protein in the tumor necrosis factor (TNF) receptor pathway, plays a key role in inflammation and cell death in response to tissue damage and pathogen recognition.
MedKoo Cat#: 463649
Name: Eclitasertib
CAS#: 2125450-76-0
Chemical Formula: C19H18N6O3
Exact Mass: 378.1440
Molecular Weight: 378.39
Elemental Analysis: C, 60.31; H, 4.80; N, 22.21; O, 12.68
The following data is based on the product molecular weight 378.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
