GW809897X | CAS#unknown | VEGFR2 tyrosine kinase inhibitor

MedKoo Cat#: 463609 | Name: GW809897X

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GW809897X is a novel and potent inhibitor of VEGFR2 tyrosine kinase, non-selectively inhibiting AURKA and AURKB.

Chemical Structure

GW809897X

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463609

Name: GW809897X

CAS#: unknown

Chemical Formula: C26H24Cl2N6O3S

Exact Mass: 570.1008

Molecular Weight: 571.48

Elemental Analysis: C, 54.65; H, 4.23; Cl, 12.41; N, 14.71; O, 8.40; S, 5.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GW809897X; GW-809897X; GW 809897X;

IUPAC/Chemical Name

1-(2,6-dichlorophenyl)-3-(4-(methyl(2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)urea

InChi Key

NXPQZPWXVHIWGN-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H24Cl2N6O3S/c1-34(20-11-9-18(10-12-20)31-26(35)33-24-21(27)7-4-8-22(24)28)23-13-14-29-25(32-23)30-19-6-3-5-17(15-19)16-38(2,36)37/h3-15H,16H2,1-2H3,(H,29,30,32)(H2,31,33,35)

SMILES Code

O=C(NC1=CC=C(N(C)C2=NC(NC3=CC=CC(CS(=O)(C)=O)=C3)=NC=C2)C=C1)NC4=C(Cl)C=CC=C4Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 571.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Moreira-Nunes CA, Mesquita FP, Portilho AJS, Mello Júnior FAR, Maués JHDS, Pantoja LDC, Wanderley AV, Khayat AS, Zuercher WJ, Montenegro RC, de Moraes- Filho MO, de Moraes MEA. Targeting aurora kinases as a potential prognostic and therapeutical biomarkers in pediatric acute lymphoblastic leukaemia. Sci Rep. 2020 Dec 4;10(1):21272. doi: 10.1038/s41598-020-78024-8. PMID: 33277547; PMCID: PMC7718893.