MedKoo Cat#: 412710 | Name: Azelaoyl-PAF
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Azelaoyl-PAF is a potent PPARγ agonist. Azelaoyl PAF has been used to investigate whether peroxisome proliferator-activated receptors gamma agonists could play a role in the treatment of Friedreich′s ataxia, a neurodegenerative disease due to frataxin deficiency.

Chemical Structure

Azelaoyl-PAF
Azelaoyl-PAF
CAS#354583-69-0

Theoretical Analysis

MedKoo Cat#: 412710

Name: Azelaoyl-PAF

CAS#: 354583-69-0

Chemical Formula: C33H66NO9P

Exact Mass: 651.4475

Molecular Weight: 651.86

Elemental Analysis: C, 60.80; H, 10.21; N, 2.15; O, 22.09; P, 4.75

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
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Synonym
Azelaoyl-PAF
IUPAC/Chemical Name
(R)-2-((8-carboxyoctanoyl)oxy)-3-(hexadecyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
InChi Key
ZDFOCDTXDPKJKA-WJOKGBTCSA-N
InChi Code
InChI=1S/C33H66NO9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-20-23-27-40-29-31(30-42-44(38,39)41-28-26-34(2,3)4)43-33(37)25-22-19-17-18-21-24-32(35)36/h31H,5-30H2,1-4H3,(H-,35,36,38,39)/t31-/m1/s1
SMILES Code
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCC(O)=O)=O)COCCCCCCCCCCCCCCCC)=O
Appearance
A solution in ethanol
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 651.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Marmolino D, Acquaviva F, Pinelli M, Monticelli A, Castaldo I, Filla A, Cocozza S. PPAR-gamma agonist Azelaoyl PAF increases frataxin protein and mRNA expression: new implications for the Friedreich's ataxia therapy. Cerebellum. 2009 Jun;8(2):98-103. doi: 10.1007/s12311-008-0087-z. Epub 2008 Dec 23. PMID: 19104905. 2: Ghodsian N, Yeandle A, Hock BD, Gieseg SP. CD36 down regulation by the macrophage antioxidant 7,8-dihydroneopterin through modulation of PPAR-γ activity. Free Radic Res. 2022 May-Jun;56(5-6):366-377. doi: 10.1080/10715762.2022.2114904. Epub 2022 Aug 28. PMID: 36017639.