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MedKoo Cat#: 463600 | Name: Penehyclidine hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Penehyclidine hydrochloride is a selective M1 and M3 receptor antagonist, preventing soman-induced electroencephalographic seizures.

Chemical Structure

Penehyclidine hydrochloride
Penehyclidine hydrochloride
CAS#151937-76-7

Theoretical Analysis

MedKoo Cat#: 463600

Name: Penehyclidine hydrochloride

CAS#: 151937-76-7

Chemical Formula: C20H30ClNO2

Exact Mass: 351.1965

Molecular Weight: 351.92

Elemental Analysis: C, 68.26; H, 8.59; Cl, 10.07; N, 3.98; O, 9.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Penehyclidine hydrochloride; Penehyclidine-hydrochloride; Penehyclidine HCl; Penehyclidine-HCl;
IUPAC/Chemical Name
1-cyclopentyl-1-phenyl-2-(quinuclidin-3-yloxy)ethan-1-ol hydrochloride
InChi Key
DDTVVMRZNVIVQM-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H29NO2.ClH/c22-20(18-8-4-5-9-18,17-6-2-1-3-7-17)15-23-19-14-21-12-10-16(19)11-13-21;/h1-3,6-7,16,18-19,22H,4-5,8-15H2;1H
SMILES Code
OC(C1CCCC1)(C2=CC=CC=C2)COC3C4CCN(CC4)C3.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 351.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang X, Liu F, Xu M, Wu L. Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute respiratory distress syndrome in cells via regulating autophagy‑related pathway. Mol Med Rep. 2021 Feb;23(2):100. doi: 10.3892/mmr.2020.11739. Epub 2020 Dec 10. PMID: 33300058. 2: Yao YT, Ying H, Fang NX, Zhang YB, Yuan X. Penehyclidine Hydrochloride Premedication Is Not Associated with Increased Incidence of Post-Operative Cognitive Dysfunction or Delirium:A Systemic Review and Meta-Analysis. Chin Med Sci J. 2020 Jun 30;35(2):121-134. doi: 10.24920/003630. PMID: 32684232. 3: Liu Z, Li Y, Yu L, Chang Y, Yu J. Penehyclidine hydrochloride inhibits renal ischemia/reperfusion-induced acute lung injury by activating the Nrf2 pathway. Aging (Albany NY). 2020 Jul 11;12(13):13400-13421. doi: 10.18632/aging.103444. Epub 2020 Jul 11. PMID: 32652517; PMCID: PMC7377887. 4: Kang Y, Li Y, Wen H, Zhu J, Zheng J, Feng Z. Prevention of renal ischemia and reperfusion injury by penehyclidine hydrochloride through autophagy activation. Mol Med Rep. 2020 May;21(5):2182-2192. doi: 10.3892/mmr.2020.11024. Epub 2020 Mar 12. PMID: 32186764; PMCID: PMC7115187. 5: Zi C, Zhang C, Yang Y, Ma J. Penehyclidine hydrochloride protects against anoxia/reoxygenation injury in cardiomyocytes through ATP-sensitive potassium channels, and the Akt/GSK-3β and Akt/mTOR signaling pathways. Cell Biol Int. 2020 Jun;44(6):1353-1362. doi: 10.1002/cbin.11329. Epub 2020 Mar 16. PMID: 32125033. 6: Ren JY, Lin DM, Wang CB, Yang YL, Wang ZQ, Cui BQ, Ma J. Postconditioning Protection Against Myocardiocyte Anoxia/Reoxygenation Injury From Penehyclidine Hydrochloride. Drug Des Devel Ther. 2019 Nov 26;13:3977-3988. doi: 10.2147/DDDT.S224282. PMID: 32063699; PMCID: PMC6884978. 7: Fu C, Zhang X, Pei Q, Guo C, Yang X, Yang S, Huang J, Yang G. Safety of the muscarinic receptor-antagonist (R,R)-penehyclidine fumarate in healthy subjects: A phase 1 randomized, double-blind, single-dose escalation study. Int J Clin Pharmacol Ther. 2020 Mar;58(3):155-165. doi: 10.5414/CP203535. PMID: 31724530. 8: Sun X, Sun C, Zhai L, Dong W. A Selective M1 and M3 Receptor Antagonist, Penehyclidine Hydrochloride, Exerts Antidepressant-Like Effect in Mice. Neurochem Res. 2019 Dec;44(12):2723-2732. doi: 10.1007/s11064-019-02891-5. Epub 2019 Oct 12. PMID: 31606838. 9: Zhao H, Wang P, Ma C, Wang C. Smoking Attenuates Efficacy of Penehyclidine Hydrochloride in Acute Respiratory Distress Syndrome Induced by Lipopolysaccharide in Rats. Med Sci Monit. 2019 Sep 28;25:7295-7305. doi: 10.12659/MSM.917037. PMID: 31562811; PMCID: PMC6784682. 10: Li L, Li Q, Wei L, Wang Z, Ma W, Liu F, Shen Y, Zhang S, Zhang X, Li H, Qian Y. Dexamethasone combined with berberine is an effective therapy for bleomycin- induced pulmonary fibrosis in rats. Exp Ther Med. 2019 Oct;18(4):2385-2392. doi: 10.3892/etm.2019.7861. Epub 2019 Aug 7. PMID: 31555349; PMCID: PMC6755270. 11: Weng J, Chen M, Lin Q, Chen J, Wang S, Fang D. Penehyclidine hydrochloride defends against LPS-induced ALI in rats by mitigating endoplasmic reticulum stress and promoting the Hes1/Notch1 pathway. Gene. 2019 Dec 30;721:144095. doi: 10.1016/j.gene.2019.144095. Epub 2019 Aug 30. PMID: 31476403. 12: Ye S, Yang X, Wang Q, Chen Q, Ma Y. Penehyclidine Hydrochloride Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Ameliorating Apoptosis and Endoplasmic Reticulum Stress. J Surg Res. 2020 Jan;245:344-353. doi: 10.1016/j.jss.2019.07.080. Epub 2019 Aug 16. PMID: 31425874. 13: Hongyu X, Qingting W, Xiaoling S, Liwu Z, Ailing Y, Xin L. Penehyclidine hydrochloride on postoperatively cognitive function. Med Hypotheses. 2019 Aug;129:109246. doi: 10.1016/j.mehy.2019.109246. Epub 2019 May 25. PMID: 31371081. 14: Lewis SR, Pritchard MW, Thomas CM, Smith AF. Pharmacological agents for adults with acute respiratory distress syndrome. Cochrane Database Syst Rev. 2019 Jul 23;7(7):CD004477. doi: 10.1002/14651858.CD004477.pub3. PMID: 31334568; PMCID: PMC6646953. 15: Qs L, K C, Ap L, F X, Qw H, Z L, Qh Y, Yl W, Zz Z, J Z. Roles of M3 receptor in the effect of penehyclidine hydrochloride upregulated beta-arrestin-1 expression in LPS-stimulated HPMVEC. J Recept Signal Transduct Res. 2019 Feb;39(1):39-44. doi: 10.1080/10799893.2019.1597115. Epub 2019 Jun 25. PMID: 31237798. 16: Zheng SH, Yan CY, Duan N, Wang W, Mei XP. Penehyclidine hydrochloride suppressed peripheral nerve injury-induced neuropathic pain by inhibiting microglial MAPK/p-p38/IL-1β pathway activation. Mol Pain. 2019 Jan- Dec;15:1744806919858260. doi: 10.1177/1744806919858260. PMID: 31149893; PMCID: PMC6589961. 17: Kong Q, Wu X, Duan W, Zhan L, Song X. Penehyclidine hydrochloride exerts protective effects in rats with acute lung injury via the Fas/FasL signaling pathway. Exp Ther Med. 2019 May;17(5):3598-3606. doi: 10.3892/etm.2019.7340. Epub 2019 Mar 4. PMID: 30988742; PMCID: PMC6447765. 18: Wu X, Kong Q, Xia Z, Zhan L, Duan W, Song X. Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute lung injury in rats: Potential role of caveolin‑1 expression upregulation. Int J Mol Med. 2019 May;43(5):2064-2074. doi: 10.3892/ijmm.2019.4117. Epub 2019 Mar 1. PMID: 30864740; PMCID: PMC6443352. 19: Sun YL, Li TK, Li CS, Lü SG, Wang L, Lu XH. [Effects of penehyclidine hydrochloride on Nrf2/ARE signaling pathway during endotoxin-induced acute lung injury in neonate rats]. Zhonghua Yi Xue Za Zhi. 2019 Feb 12;99(6):453-457. Chinese. doi: 10.3760/cma.j.issn.0376-2491.2019.06.014. PMID: 30786341. 20: Xiao H, Shi T, Han L, Tong R, Liao Z. Mechanism of penehyclidine hydrochloride on a dysmenorrhea rat model. Drug Dev Res. 2019 May;80(3):325-332. doi: 10.1002/ddr.21500. Epub 2018 Dec 3. PMID: 30511353.

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RK-0404678

RK-0404678