Fandosentan | CAS# 221241-63-0 | Biochemical

MedKoo Cat#: 575317 | Name: Fandosentan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fandosentan is an endothelin receptor antagonist.

Chemical Structure

Fandosentan

CAS#221241-63-0

Theoretical Analysis

MedKoo Cat#: 575317

Name: Fandosentan

CAS#: 221241-63-0

Chemical Formula: C25H18F3NO6S

Exact Mass: 517.0807

Molecular Weight: 517.48

Elemental Analysis: C, 58.03; H, 3.51; F, 11.01; N, 2.71; O, 18.55; S, 6.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Fandosentan

IUPAC/Chemical Name

4-(7-ethylbenzo[d][1,3]dioxol-5-yl)-2-(2-(trifluoromethyl)phenyl)-2H-benzo[e][1,2]thiazine-3-carboxylic acid 1,1-dioxide

InChi Key

YMGQBWRXNCAABF-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H18F3NO6S/c1-2-14-11-15(12-19-23(14)35-13-34-19)21-16-7-3-6-10-20(16)36(32,33)29(22(21)24(30)31)18-9-5-4-8-17(18)25(26,27)28/h3-12H,2,13H2,1H3,(H,30,31)

SMILES Code

CCc1cc(cc2OCOc12)C3=C(N(c4ccccc4C(F)(F)F)S(=O)(=O)c5ccccc35)C(=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 517.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Aleo MD, Ukairo O, Moore A, Irrechukwu O, Potter DM, Schneider RP. Liver safety evaluation of endothelin receptor antagonists using HepatoPac® : A single model impact assessment on hepatocellular health, function and bile acid disposition. J Appl Toxicol. 2019 Aug;39(8):1192-1207. doi: 10.1002/jat.3805. Epub 2019 May 27. PMID: 31134659.