Fadolmidine | CAS# 189353-31-9 | Biochemical

MedKoo Cat#: 575296 | Name: Fadolmidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fadolmidine is a novel and potent alpha2 -adrenoceptor (alpha2) -AR) agonist developed for spinal analgesia.

Chemical Structure

Fadolmidine

CAS#189353-31-9

Theoretical Analysis

MedKoo Cat#: 575296

Name: Fadolmidine

CAS#: 189353-31-9

Chemical Formula: C13H14N2O

Exact Mass: 214.1106

Molecular Weight: 214.27

Elemental Analysis: C, 72.87; H, 6.59; N, 13.07; O, 7.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Fadolmidine

IUPAC/Chemical Name

3-(Imidazol-4-ylmethyl)-5-indanol

InChi Key

VTZPAJGVRWKMAG-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H14N2O/c16-12-4-3-9-1-2-10(13(9)6-12)5-11-7-14-8-15-11/h3-4,6-8,10,16H,1-2,5H2,(H,14,15)

SMILES Code

Oc1ccc2CCC(Cc3c[nH]cn3)c2c1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 214.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Berg T. Angiotensin AT1 - α2C-Adrenoceptor Interaction Disturbs α2A-auto-Inhibition of Catecholamine Release in Hypertensive Rats. Front Neurol. 2013 Jun 10;4:70. doi: 10.3389/fneur.2013.00070. PubMed PMID: 23772221; PubMed Central PMCID: PMC3677154. 2: Wei H, Pertovaara A. Regulation of neuropathic hypersensitivity by α(2) -adrenoceptors in the pontine A7 cell group. Basic Clin Pharmacol Toxicol. 2013 Feb;112(2):90-5. doi: 10.1111/j.1742-7843.2012.00930.x. Epub 2012 Sep 25. PubMed PMID: 22900496. 3: Chan AK, Cheung CW, Chong YK. Alpha-2 agonists in acute pain management. Expert Opin Pharmacother. 2010 Dec;11(17):2849-68. doi: 10.1517/14656566.2010.511613. Epub 2010 Aug 13. Review. PubMed PMID: 20707597. 4: Leino T, Viitamaa T, Haapalinna A, LehtimÃ¤ki J, Virtanen R. Pharmacological profile of intrathecal fadolmidine, a alpha2-adrenoceptor agonist, in rodent models. Naunyn Schmiedebergs Arch Pharmacol. 2009 Dec;380(6):539-50. doi: 10.1007/s00210-009-0460-6. Epub 2009 Oct 14. PubMed PMID: 19826791. 5: LehtimÃ¤ki J, Leino T, Koivisto A, Viitamaa T, LehtimÃ¤ki T, Haapalinna A, Kuokkanen K, Virtanen R. In vitro and in vivo profiling of fadolmidine, a novel potent alpha(2)-adrenoceptor agonist with local mode of action. Eur J Pharmacol. 2008 Dec 3;599(1-3):65-71. doi: 10.1016/j.ejphar.2008.10.003. Epub 2008 Oct 9. PubMed PMID: 18930723.