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MedKoo Cat#: 412680 | Name: PGF2β
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PGF2β is the C-9 epimer of PGF2α, a bronchodilator that exhibits negative chronotopic activity

Chemical Structure

PGF2β
PGF2β
CAS#4510-16-1

Theoretical Analysis

MedKoo Cat#: 412680

Name: PGF2β

CAS#: 4510-16-1

Chemical Formula: C20H34O5

Exact Mass: 354.2406

Molecular Weight: 354.49

Elemental Analysis: C, 67.77; H, 9.67; O, 22.57

Price and Availability

Size Price Availability Quantity
1mg USD 252.00 2 Weeks
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Related CAS #
No Data
Synonym
PGF2β; Prostaglandin F2β
IUPAC/Chemical Name
(Z)-7-((1R,2R,3R,5R)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoic acid
InChi Key
PXGPLTODNUVGFL-JZFBHDEDSA-N
InChi Code
InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
SMILES Code
O[C@@H]1C[C@@H](O)[C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 354.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Loffredo L, Ettorre E, Zicari AM, Inghilleri M, Nocella C, Perri L, Spalice A, Fossati C, De Lucia MC, Pigozzi F, Cacciafesta M, Violi F, Carnevale R; Neurodegenerative Disease study group. Oxidative Stress and Gut-Derived Lipopolysaccharides in Neurodegenerative Disease: Role of NOX2. Oxid Med Cell Longev. 2020 Jan 31;2020:8630275. doi: 10.1155/2020/8630275. PMID: 32089785; PMCID: PMC7016401. 2: Shaker SR, Al-Amran F, Fatima G, Al-Aubaid H, Hadi NR. Trimetazidine Improves the Outcome of EECP Therapy in Patients with Refractory Angina Pectoris. Med Arch. 2020 Jun;74(3):199-204. doi: 10.5455/medarh.2020.74.199-204. PMID: 32801436; PMCID: PMC7406001. 3: Stratz C, Anakwue J, Bhatia H, Pitz S, Fiebich BL. Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes. Int Immunopharmacol. 2014 Sep;22(1):160-6. doi: 10.1016/j.intimp.2014.06.003. Epub 2014 Jun 27. PMID: 24975660. 4: Lamont JT, Ventola AS, Maull EA, Szabo S. Cysteamine and prostaglandin F2 beta stimulate rat gastric mucin release. Gastroenterology. 1983 Feb;84(2):306-13. PMID: 6184259. 5: Warberg J, Eskay RL, Barnea A, Reynolds RC, Porter JC. Release of luteinizing hormone releasing hormone and thyrotropin releasing hormone from a synaptosome- enriched fraction of hypothalamic homogenates. Endocrinology. 1977 Mar;100(3):814-25. doi: 10.1210/endo-100-3-814. PMID: 122600. 6: Gonzalez-Luis G, Perez-Vizcaino F, Blanco CE, Villamor E. Age-related changes in isoprostane-mediated relaxation of piglet blood vessels. Front Biosci (Elite Ed). 2010 Jan 1;2:369-79. doi: 10.2741/e97. PMID: 20036885. 7: Kim KM, Jung BH, Paeng KJ, Kim I, Chung BC. Increased urinary F(2)-isoprostanes levels in the patients with Alzheimer's disease. Brain Res Bull. 2004 Jul 30;64(1):47-51. doi: 10.1016/j.brainresbull.2004.04.016. PMID: 15275956. 8: Tazzeo T, Miller J, Janssen LJ. Vasoconstrictor responses, and underlying mechanisms, to isoprostanes in human and porcine bronchial arterial smooth muscle. Br J Pharmacol. 2003 Oct;140(4):759-63. doi: 10.1038/sj.bjp.0705482. Epub 2003 Sep 22. PMID: 14504139; PMCID: PMC1574071. 9: Szabo S, Gallagher GT, Horner HC, Frankel PW, Underwood RH, Konturek SJ, Brzozowski T, Trier JS. Role of the adrenal cortex in gastric mucosal protection by prostaglandins, sulfhydryls, and cimetidine in the rat. Gastroenterology. 1983 Dec;85(6):1384-90. PMID: 6605275. 10: Trier JS, Szabo S, Allan CH. Ethanol-induced damage to mucosal capillaries of rat stomach. Ultrastructural features and effects of prostaglandin F2 beta and cysteamine. Gastroenterology. 1987 Jan;92(1):13-22. doi: 10.1016/0016-5085(87)90834-1. PMID: 3781180.

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PH-002

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