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MedKoo Cat#: 412672 | Name: PGF1α
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PGF1α is the inactive, non-enzymatic hydrolysis product of PGI2.1,2 6-keto PGF1α serves as a useful marker of PGI2 biosynthesis in vivo. When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1α.

Chemical Structure

PGF1α
PGF1α
CAS#745-62-0

Theoretical Analysis

MedKoo Cat#: 412672

Name: PGF1α

CAS#: 745-62-0

Chemical Formula: C20H36O5

Exact Mass: 356.2563

Molecular Weight: 356.50

Elemental Analysis: C, 67.38; H, 10.18; O, 22.44

Price and Availability

Size Price Availability Quantity
1mg USD 241.00 2 Weeks
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Related CAS #
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Synonym
PGF1α; Prostaglandin F1α
IUPAC/Chemical Name
7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)heptanoic acid
InChi Key
DZUXGQBLFALXCR-CDIPTNKSSA-N
InChi Code
InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
SMILES Code
O[C@@H]1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 356.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang F, Zhang G, Lu Z, Geurts AM, Usa K, Jacob HJ, Cowley AW, Wang N, Liang M. Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury. Kidney Int. 2015 Oct;88(4):796-803. doi: 10.1038/ki.2015.176. Epub 2015 Jun 24. PMID: 26108065; PMCID: PMC4589441. 2: Zhu K, Zhao F, Yang Y, Mu W. Effects of simvastatin-loaded PLGA microspheres on treatment of rats with intervertebral disk degeneration and on 6-K-PGF1α and HIF-1α. Exp Ther Med. 2020 Jan;19(1):579-584. doi: 10.3892/etm.2019.8267. Epub 2019 Dec 2. PMID: 31897100; PMCID: PMC6923742. 3: Kou N, Xue M, Yang L, Zang MX, Qu H, Wang MM, Miao Y, Yang B, Shi DZ. Panax quinquefolius saponins combined with dual antiplatelet drug therapy alleviate gastric mucosal injury and thrombogenesis through the COX/PG pathway in a rat model of acute myocardial infarction. PLoS One. 2018 Mar 27;13(3):e0194082. doi: 10.1371/journal.pone.0194082. PMID: 29584740; PMCID: PMC5870954. 4: Zhang K, Wang D, Jiang Z, Ning X, Buzzacott P, Xu W. Endothelial dysfunction correlates with decompression bubbles in rats. Sci Rep. 2016 Sep 12;6:33390. doi: 10.1038/srep33390. PMID: 27615160; PMCID: PMC5018851. 5: Chen Y, Shen Y, Nie Y, Chen Z, Wang H, Liao H, Li J. Leptin upregulates COX-2 and its downstream products in aortic endothelial cells. Exp Ther Med. 2017 Nov;14(5):5097-5102. doi: 10.3892/etm.2017.5177. Epub 2017 Sep 21. PMID: 29201221; PMCID: PMC5704259. 6: Bonewald LF. Establishment and characterization of an osteocyte-like cell line, MLO-Y4. J Bone Miner Metab. 1999;17(1):61-5. doi: 10.1007/s007740050066. PMID: 10084404. 7: Xu B, Shanmugalingam R, Chau K, Pears S, Hennessy A, Makris A. The effect of acetyl salicylic acid (Aspirin) on trophoblast-endothelial interaction in vitro. J Reprod Immunol. 2017 Nov;124:54-61. doi: 10.1016/j.jri.2017.10.044. Epub 2017 Oct 18. PMID: 29055792. 8: Waitzman MB. Proposed metabolic dysfunctions in diabetic microthromboses and microangiopathy. Metabolism. 1979 Apr;28(4 Suppl 1):401-6. doi: 10.1016/0026-0495(79)90045-3. PMID: 233637. 9: Zhou Y, Guo HY, Pneg F. [Effect of Shenmai Injection on Vascular Endothelial Dependence Diastolic Function in Coronary Heart Disease Patients]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2017 Mar;37(3):302-305. Chinese. PMID: 30650479. 10: Thomas D, Suo J, Ulshöfer T, Jordan H, de Bruin N, Scholich K, Geisslinger G, Ferreirós N. Nano-LC-MS/MS for the quantitation of prostanoids in immune cells. Anal Bioanal Chem. 2014 Nov;406(28):7103-16. doi: 10.1007/s00216-014-8134-8. Epub 2014 Sep 6. PMID: 25192790.

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PGD97

PGD97