CGP 55398 | CAS# 152786-45-3 | liposomal Ge(IV) phthalocyanine

MedKoo Cat#: 412660 | Name: CGP 55398

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP 55398 is a liposomal Ge(IV) phthalocyanine bearing two axially ligated cholesterol moieties.

Chemical Structure

CGP 55398

CAS#152786-45-3

Theoretical Analysis

MedKoo Cat#: 412660

Name: CGP 55398

CAS#: 152786-45-3

Chemical Formula: C110H128GeN8O4Si2

Exact Mass: 1754.8809

Molecular Weight: 1755.09

Elemental Analysis: C, 75.28; H, 7.35; Ge, 4.14; N, 6.38; O, 3.65; Si, 3.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CGP 55398; CGP-55398; CGP55398

IUPAC/Chemical Name

Germanium, bis((((3beta)-cholest-4-en-3-yl)oxy)diphenylsilanolato)(29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32)-, (OC-6-12)-

InChi Key

DRZRKFGOKLNVEV-UHFFFAOYSA-N

InChi Code

InChI=1S/C110H128GeN8O4Si2/c1-71(2)33-31-35-73(5)93-57-59-95-91-55-53-75-69-77(61-65-107(75,7)97(91)63-67-109(93,95)9)120-124(79-37-15-11-16-38-79,80-39-17-12-18-40-80)122-111(123-125(81-41-19-13-20-42-81,82-43-21-14-22-44-82)121-78-62-66-108(8)76(70-78)54-56-92-96-60-58-94(74(6)36-32-34-72(3)4)110(96,10)68-64-98(92)108)116-99-83-45-23-24-46-84(83)100(116)113-102-87-49-27-28-50-88(87)104(118(102)111)115-106-90-52-30-29-51-89(90)105(119(106)111)114-103-86-48-26-25-47-85(86)101(112-99)117(103)111/h11-30,37-54,71-74,77-78,91-98,116,119H,31-36,55-70H2,1-10H3

SMILES Code

CC(CCCC(C1CCC2C3CC=C4CC(O[Si](c5ccccc5)([O-][Ge+4]678([O-][Si](c9ccccc9)(c%10ccccc%10)OC%11CCC%12(C%13CCC%14(C(C(CCCC(C)C)C)CCC%14C%13CC=C%12C%11)C)C)N%15=C%16N=C%17c%18c(C([N-]8%17)=NC%19=N6C(c%20c%19cccc%20)=NC%21=C%22C=CC=CC%22=C([N-]7%21)N=C%15c%23c%16cccc%23)cccc%18)c%24ccccc%24)CCC4(C3CCC12C)C)C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,755.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Segalla A, Milanesi C, Jori G, Capraro HG, Isele U, Schieweck K. CGP 55398, a liposomal Ge(IV) phthalocyanine bearing two axially ligated cholesterol moieties: a new potential agent for photodynamic therapy of tumours. Br J Cancer. 1994 May;69(5):817-25. doi: 10.1038/bjc.1994.160. PMID: 8180009; PMCID: PMC1968893. 2: Seotsanyana-Mokhosi I, Kresfelder T, Abrahamse H, Nyokong T. The effect of Ge, Si and Sn phthalocyanine photosensitizers on cell proliferation and viability of human oesophageal carcinoma cells. J Photochem Photobiol B. 2006 Apr 3;83(1):55-62. doi: 10.1016/j.jphotobiol.2005.12.004. Epub 2006 Jan 25. PMID: 16442300.