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MedKoo Cat#: 463563 | Name: Anhydroleucovorin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Anhydroleucovorin, also known as 5,10-Methenyltetrahydrofolate (5,10-CH=THF), is a form of tetrahydrofolate that is an intermediate in metabolism. 5,10-CH=THF is a coenzyme that accepts and donates methenyl (CH=) groups. It is produced from 5,10-methylenetetrahydrofolate by either a NAD+ dependent methylenetetrahydrofolate dehydrogenase, or a NADP+ dependent dehydrogenase. It can also be produced as an intermediate in histidine catabolism, by formiminotransferase cyclodeaminase, from 5-formiminotetrahydrofolate. 5,10-CH=THF is a substrate for methenyltetrahydrofolate cyclohydrolase, which converts it into 10-formyltetrahydrofolate.

Chemical Structure

Anhydroleucovorin
Anhydroleucovorin
CAS#7444-29-3

Theoretical Analysis

MedKoo Cat#: 463563

Name: Anhydroleucovorin

CAS#: 7444-29-3

Chemical Formula: C20H21N7O6

Exact Mass: 455.1553

Molecular Weight: 455.43

Elemental Analysis: C, 52.75; H, 4.65; N, 21.53; O, 21.08

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 650.00 2 Weeks
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Related CAS #
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Synonym
Anhydroleucovorin; 5,10-Methenyltetrahydrofolate; Anhydroleucovorin A; 5,10-methenyl-THF
IUPAC/Chemical Name
(S)-2-(4-((R)-3-amino-1-oxo-1,4,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8-ium-8-yl)benzamido)-4-carboxybutanoate
InChi Key
MEANFMOQMXYMCT-OLZOCXBDSA-N
InChi Code
InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/t12-,13+/m1/s1
SMILES Code
O=C1C2=C(NC(N)=N1)NC[C@]3(N2C=[N+](C3)C4=CC=C(C=C4)C(N[C@@H](CCC(O)=O)C([O-])=O)=O)[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 455.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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