Synonym
Isazofos; CCRIS8221; CCRIS-8221 CCRIS 8221
IUPAC/Chemical Name
O-(5-Chloro-1-isopropyl-1,2,4-triazol-3-yl) O,O-diethyl phosphorothioate
InChi Key
XRHGWAGWAHHFLF-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H17ClN3O3PS/c1-5-14-17(18,15-6-2)16-9-11-8(10)13(12-9)7(3)4/h7H,5-6H2,1-4H3
SMILES Code
S=P(OCC)(OC1=NN(C(C)C)C(Cl)=N1)OCC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
313.74
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Seok SH, Park JH, Cho SA, Kim DJ, Bae BK, Park JH. Risk assessment of the organophosphate pesticides isazofos and pyraclofos using a 21-day dietary toxicity study in Japanese quail. Ecotoxicol Environ Saf. 2008 Sep;71(1):245-51. doi: 10.1016/j.ecoenv.2007.05.015. Epub 2007 Jul 16. PMID: 17629558.
2: Blackburn K, Alm SR, Yeh TS, Dawson CG. High-pressure Liquid Injection of Isazofos for Management of Hoplolaimus galeatus and Tylenchorhynchus dubius Infesting Turfgrasses. J Nematol. 1997 Dec;29(4S):690-4. PMID: 19274270; PMCID: PMC2619827.
3: Olsson AO, Nguyen JV, Sadowski MA, Barr DB. A liquid chromatography/electrospray ionization-tandem mass spectrometry method for quantification of specific organophosphorus pesticide biomarkers in human urine. Anal Bioanal Chem. 2003 Jul;376(6):808-15. doi: 10.1007/s00216-003-1978-y. Epub 2003 Jun 17. PMID: 12811448.
4: Greco N, Elia F, Brandonisio A. Control of Heterodera carotae, Ditylenchus dipsaci, and Meloidogyne javanica with Fumigant and Nonfumigant Nematicides. J Nematol. 1986 Jul;18(3):359-63. PMID: 19294191; PMCID: PMC2618554.
5: Abo-Amer A. Biodegradation of diazinon by Serratia marcescens DI101 and its use in bioremediation of contaminated environment. J Microbiol Biotechnol. 2011 Jan;21(1):71-80. doi: 10.4014/jmb.1007.07024. PMID: 21301195.
6: Blackburn K, Alm SR, Yeh TS. Avermectin B1, Isazofos, and Fenamiphos for Control of Hoplolaimus galeatus and Tylenchorhynchus dubius Infesting Poa annua. J Nematol. 1996 Dec;28(4S):687. PMID: 19277196; PMCID: PMC2619729.
7: Karpouzas DG, Morgan JA, Walker A. Isolation and characterisation of ethoprophos-degrading bacteria. FEMS Microbiol Ecol. 2000 Sep 1;33(3):209-218. doi: 10.1111/j.1574-6941.2000.tb00743.x. PMID: 11098072.
8: Singh BK, Walker A, Morgan JA, Wright DJ. Biodegradation of chlorpyrifos by enterobacter strain B-14 and its use in bioremediation of contaminated soils. Appl Environ Microbiol. 2004 Aug;70(8):4855-63. doi: 10.1128/AEM.70.8.4855-4863.2004. PMID: 15294824; PMCID: PMC492451.
9: Karpouzas DG, Fotopoulou A, Menkissoglu-Spiroudi U, Singh BK. Non-specific biodegradation of the organophosphorus pesticides, cadusafos and ethoprophos, by two bacterial isolates. FEMS Microbiol Ecol. 2005 Aug 1;53(3):369-78. doi: 10.1016/j.femsec.2005.01.012. PMID: 16329956.
10: Zamy C, Mazellier P, Legube B. Phototransformation of selected organophosphorus pesticides in dilute aqueous solutions. Water Res. 2004 May;38(9):2304-13. doi: 10.1016/j.watres.2004.02.019. PMID: 15142791.
