Synonym
Supidimide; CG3033; CG-3033; CG 3033
IUPAC/Chemical Name
1,2-Benzisothiazolin-3-one, 2-(2-oxo-3-piperidyl)-, 1,1-dioxide
InChi Key
QQWLXNMPPFCVCD-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H12N2O4S/c15-11-9(5-3-7-13-11)14-12(16)8-4-1-2-6-10(8)19(14,17)18/h1-2,4,6,9H,3,5,7H2,(H,13,15)
SMILES Code
O=C(C1=C2C=CC=C1)N(C3C(NCCC3)=O)S2(=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
280.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Youdim MB, Ashkenazi R. Serotonergic involvement in pharmacological action of the anxiolytic-sedatives thalidomide and supidimide. Eur J Pharmacol. 1985 Dec 10;119(1-2):39-46. doi: 10.1016/0014-2999(85)90319-x. PMID: 2867921.
2: Hennies HH, Günzler WA, Flohé L. Influence of supidimide on brain neurotransmitter systems of rats and mice. Arzneimittelforschung. 1984;34(11):1471-80. PMID: 6084511.
3: Guex-Crosier Y, Pittet N, Herbort CP. The effect of thalidomide and supidimide on endotoxin-induced uveitis in rats. Graefes Arch Clin Exp Ophthalmol. 1995 Feb;233(2):90-3. doi: 10.1007/BF00241478. PMID: 7729710.
4: Becker R, Frankus E, Graudums I, Günzler WA, Helm FC, Flohé L. The metabolic fate of supidimide in the rat. Arzneimittelforschung. 1982;32(9):1101-11. PMID: 6890834.
5: Rapisarda V, Aguglia E, Poma A. Effects of supidimide in schizophrenic inpatients undergoing neuroleptic maintenance therapy with haloperidol. Eur J Clin Pharmacol. 1982;22(3):217-23. doi: 10.1007/BF00545218. PMID: 7049709.
6: Hennies HH, Hess V, Flohé L. Antagonism by supidimide of haloperidol-induced augmentation of [3H]-spiperone binding in rat striatum. Arzneimittelforschung. 1984;34(11):1481-4. PMID: 6543122.
7: Paul F, Lücker PW, Richter W. Untersuchung der motilitätshemmenden und cytoprotektiven Wirkung von Supidimid auf den menschlichen Magen [Inhibition of motility and cytoprotective action of supidimide in the human stomach]. Methods Find Exp Clin Pharmacol. 1983 Oct;5(8):555-8. German. PMID: 6664155.
8: Schwab BW, Arezzo JC, Paldino AM, Flohe L, Matthiessen T, Spencer PS. Rabbit sural nerve responses to chronic treatment with thalidomide and supidimide. Muscle Nerve. 1984 Jun;7(5):362-8. doi: 10.1002/mus.880070504. PMID: 6330547.
9: Lienenlüke B, Stojanovic T, Fiebig T, Fayyazi A, Germann T, Hecker M. Thalidomide impairment of trinitrobenzene sulphonic acid-induced colitis in the rat - role of endothelial cell-leukocyte interaction. Br J Pharmacol. 2001 Aug;133(8):1414-23. doi: 10.1038/sj.bjp.0704193. PMID: 11498529; PMCID: PMC1621145.
10: Sheskin J, Mückter H, Frankus E. Supidimid, ein nicht teratogenes Thalidomidanalog zur Behandlung der Leprareaktion? [Supidimide, a non- teratogenic thalidomide analog for the treatment of leprosy reaction?]. Hautarzt. 1983 Apr;34(4):168-70. German. PMID: 6853166.
