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MedKoo Cat#: 412627 | Name: Tiomergine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tiomergine is a dopamine receptor agonist. Tiomergine modifies brain glucose metabolism in a way similar to the neuroleptics but different from postsynaptic agonists.

Chemical Structure

Tiomergine
CAS#57935-49-6

Theoretical Analysis

MedKoo Cat#: 412627

Name: Tiomergine

CAS#: 57935-49-6

Chemical Formula: C21H21N3S

Exact Mass: 347.1456

Molecular Weight: 347.48

Elemental Analysis: C, 72.59; H, 6.09; N, 12.09; S, 9.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tiomergine; CF25397; CF-25397; CF 25397
IUPAC/Chemical Name
9,10-Didehydro-6-methyl-8 beta-(2-pyridylthiomethyl)ergoline
InChi Key
VCRAKEDGLIINLR-AUUYWEPGSA-N
InChi Code
InChI=1S/C21H21N3S/c1-24-12-14(13-25-20-7-2-3-8-22-20)9-17-16-5-4-6-18-21(16)15(11-23-18)10-19(17)24/h2-9,11,14,19,23H,10,12-13H2,1H3/t14-,19-/m1/s1
SMILES Code
[H][C@@]1(N(C)C[C@H](CSC2=NC=CC=C2)C=C13)CC4=CNC5=C4C3=CC=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 347.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tamminga CA, Chase TN. Bromocriptine and CF 25-397 in the treatment of tardive dyskinesia. Arch Neurol. 1980 Apr;37(4):204-5. doi: 10.1001/archneur.1980.00500530042004. PMID: 6102461. 2: Frattola L, Albizzati MG, Bassi S, Spano PF, Trabucchi M. Treatment of dyskinetic and dystonic disorders with CF 25-397: clinical and pharmacological aspects. Adv Biochem Psychopharmacol. 1980;23:381-6. PMID: 6446848. 3: Palacios JM, Wiederhold KH. Presynaptic dopaminergic agonists modify brain glucose metabolism in a way similar to the neuroleptics. Neurosci Lett. 1984 Sep 7;50(1-3):223-9. doi: 10.1016/0304-3940(84)90490-7. PMID: 6149502.